Embryonic stem cell (ESC) markers are molecules specifically expressed in ES cells.
Understanding of the functions of these markers is critical for characterization and …

The molecular regulation of zygotic genome activation (ZGA) in mammals remains an
exciting area of research. Primed mouse embryonic stem cells contain a rare subset of “2C …

The temporal order of DNA replication (replication timing [RT]) is highly coupled with
genome architecture, but cis-elements regulating either remain elusive. We created a series …

Mammalian SWI/SNF [also called BAF (Brg/Brahma-associated factors)] ATP-dependent
chromatin remodeling complexes are essential for formation of the totipotent and pluripotent …

After fertilization of the transcriptionally silent oocyte, expression from both parental
chromosomes is launched through zygotic genome activation (ZGA), occurring in the mouse …

Monozygotic (MZ) twins and higher-order multiples arise when a zygote splits during pre-
implantation stages of development. The mechanisms underpinning this event have …

Putative RNA-binding proteins (RBPs), zygote arrested-1 (ZAR1), and ZAR2 (also known as
ZAR1L), have been identified as maternal factors that mainly function in oogenesis and …

Human embryonic stem cells (hESCs) can serve as a potentially limitless source of cells that
may enable regeneration of diseased tissue and organs. Here we investigate the use of …

The molecular mechanism controlling the zygotic genome activation (ZGA) in mammals
remains poorly understood. The 2-cell (2C)-like cells spontaneously emerging from cultures …

Mice deficient for all ten-eleven translocation (TET) genes exhibit early gastrulation lethality.
However, separating cause and effect in such embryonic failure is challenging. To isolate …