This paper is the 28th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning over a quarter-century of research. It …

Objective The clinical management of inflammatory pain requires an optimal balance
between effective analgesia and associated safety risks. To date, mechanisms associated …

Pharmacological and genetic tools targeting the 5-hydroxytryptamine (5-HT) 7 receptor in
preclinical animal models have implicated this receptor in diverse (patho) physiological …

This work aimed to evaluate the potential role of the 5-HT7 receptor in nociception
secondary to a sensitizing stimulus in mice. For this purpose, the effects of relevant ligands …

Rectal drug delivery is an effective alternative to oral and parenteral treatments. This route
allows for both local and systemic drug therapy. Traditional rectal dosage formulations have …

Efficacy of ketoprofen vs. ibuprofen and diclofenac: a systematic review of the literature and
meta-analysis Page 1 Clinical and Experimental Rheumatology 2013; 31: 731-738. Efficacy of …

Ketoprofen is a drug belonging to the family of non-steroidal anti-inflammatory drugs
(NSAIDs). The present review examines the main available clinical evidence of ketoprofen …

The involvement of the 5-HT7 receptor in nociception and pain, particularly chronic pain (ie,
neuropathic pain), has been poorly investigated. In the present study, we examined whether …

The performance of free Candida antarctica lipase B (CALB) in a mixed solvent system for
enantioselective esterification of (R)-ketoprofen, leaving the target product (S)-ketoprofen in …

The antinociceptive activity of dexketoprofen was studied in mice using the acetic acid
writhing test (acute tonic pain), the tail flick test (acute phasic pain) and the formalin assay …