Despite efforts to develop new antibiotics, antibacterial resistance still develops too fast for
drug discovery to keep pace. Often, resistance against a new drug develops even before it …

Aminoglycosides are a group of antibiotics used since the 1940s to primarily treat a broad
spectrum of bacterial infections. The primary resistance mechanism against these antibiotics …

General control non-repressible 5 (GCN5)-related N-acetyltransferases (GNAT) catalyze the
transfer of an acyl moiety from acyl coenzyme A (acyl-CoA) to a diverse group of substrates …

There is urgent need for new therapeutic strategies to fight the global threat of antibiotic
resistance. The focus of this Perspective is on chemical agents that target the most common …

A systematic analysis of all synthetic and chemoenzymatic methodologies for the
preparation of aminoglycosides for a variety of applications (therapeutic and agricultural) …

Antibiotic resistance mediated by bacterial enzymes constitutes an unmet clinical challenge
for public health, particularly for those currently used antibiotics that are recognized as “last …

Klebsiella pneumoniae is the causative agent of community-and, more commonly, hospital-
acquired infections. Infections caused by this bacterium have recently become more …

Growing resistance to antimicrobial medicines is a critical health problem that must be
urgently addressed. Adding to the increasing number of patients that succumb to infections …

Gram-negative pathogens resistant to amikacin and other aminoglycosides of clinical
relevance usually harbor the 6'-N-acetyltransferase type Ib [AAC (6')-Ib], an enzyme that …

Clinical resistance to amikacin and other aminoglycosides is usually due to the enzymatic
acetylation of the antimicrobial molecule. A ubiquitous resistance enzyme among Gram …