Regulation of placental development and its impact on fetal growth—new insights from mouse models

L Woods, V Perez-Garcia, M Hemberger - Frontiers in endocrinology, 2018 - frontiersin.org
The placenta is the chief regulator of nutrient supply to the growing embryo during gestation.
As such, adequate placental function is instrumental for developmental progression …

Placental growth factor and pre-eclampsia

K Chau, A Hennessy, A Makris - Journal of human hypertension, 2017 - nature.com
Placental growth factor (PlGF) is an increasingly important molecule in the prediction,
diagnosis and treatment of pre-eclampsia. It has pro-angiogenic effects on the feto-placental …

[HTML][HTML] VEGFR1 signaling in retinal angiogenesis and microinflammation

A Uemura, M Fruttiger, PA d'Amore, S De Falco… - Progress in retinal and …, 2021 - Elsevier
Five vascular endothelial growth factor receptor (VEGFR) ligands (VEGF-A,-B,–C,-D, and
placental growth factor [PlGF]) constitute the VEGF family. VEGF-A binds VEGF receptors 1 …

PlGF immunological impact during pregnancy

L Albonici, M Benvenuto, C Focaccetti, L Cifaldi… - International Journal of …, 2020 - mdpi.com
During pregnancy, the mother's immune system has to tolerate the persistence of paternal
alloantigens without affecting the anti-infectious immune response. Consequently, several …

Dietary Folic Acid Supplementation Attenuates Maternal High-Fat Diet-Induced Fetal Intrauterine Growth Retarded via Ameliorating Placental Inflammation and …

H Zhang, X Zhang, Y Wang, X Zhao, L Zhang, J Li… - Nutrients, 2023 - mdpi.com
The placenta is particularly susceptible to inflammation and oxidative stress, leading to
placental vascular dysfunction and placental insufficiency, which is associated with fetal …

Placental growth factor regulates the generation of TH17 cells to link angiogenesis with autoimmunity

SA Yoo, M Kim, MC Kang, JS Kong, KM Kim, S Lee… - Nature …, 2019 - nature.com
Helper T cells actively communicate with adjacent cells by secreting soluble mediators, yet
crosstalk between helper T cells and endothelial cells remains poorly understood. Here we …

Placental growth factor (PlGF) as an angiogenic/inflammatory switcher: lesson from early pregnancy losses

HR Nejabati, Z Latifi, T Ghasemnejad… - Gynecological …, 2017 - Taylor & Francis
Placental growth factor (PlGF) is an angiogenic factor which belongs to vascular endothelial
growth factor (VEGF) family. In addition to the angiogenic function of PlGF, in some …

Highly deleterious variations in COX1, CYTB, SCG5, FK2, PRL and PGF genes are the potential adaptation of the immigrated African ostrich population

MBS Al-Shuhaib, FR Al-Kafajy, MA Badi… - Computers in biology …, 2018 - Elsevier
Because of variable inconvenient living conditions in some places around the world, it is
difficult to collect reliable physiological data for ostriches. Therefore, this study aims to …

Adaptive structural and functional evolution of the placenta protects fetal growth in high-elevation deer mice

K Wilsterman, EC Moore… - Proceedings of the …, 2023 - National Acad Sciences
Environmental hypoxia challenges female reproductive physiology in placental mammals,
increasing rates of gestational complications. Adaptation to high elevation has limited many …

Placental Angiogenic Factors Are Associated With Maternal Thyroid Function and Modify hCG-Mediated FT4 Stimulation

TIM Korevaar, EAP Steegers… - The Journal of …, 2015 - academic.oup.com
Context: The thyroid has a high vascular density and this vascularity may be influenced by
pregnancy-specific angiogenic factors. Proangiogenic placental growth factor (PlGF) and …