The tumor microenvironment (TME) is essential for immune escape by tumor cells. It plays
essential roles in tumor development and metastasis. The clinical outcomes of tumors are …

CRISPR-based technologies represent a major breakthrough in biomedical science as they
offer a powerful platform for unbiased screening and functional genomics in various fields …

Maintenance of tissue homeostasis is dependent on the communication between stem cells
and supporting cells in the same niche. Regulatory T cells (Treg cells) are emerging as a …

Nutrients are emerging regulators of adaptive immunity. Selective nutrients interplay with
immunological signals to activate mechanistic target of rapamycin complex 1 (mTORC1), a …

CD8+ T cells provide host protection against pathogens by differentiating into distinct
effector and memory cell subsets, but how chromatin is site-specifically remodeled during …

Highly coordinated changes in gene expression underlie T cell activation and exhaustion.
However, the mechanisms by which such programs are regulated and how these may be …

Hematological malignancies are a highly heterogeneous group of diseases with varied
molecular and phenotypical characteristics. SWI/SNF (SWItch/Sucrose Non-Fermentable) …

The discovery of FOXP3+ regulatory T (Treg) cells as a distinct cell lineage with a central
role in regulating immune responses provided a deeper understanding of self-tolerance …

The incidence and mortality of cancer are the major health issue worldwide. Apart from the
treatments developed to date, the unsatisfactory therapeutic effects of cancers have not …

The transcription factor Foxp3 plays crucial roles for Treg cell development and function.
Conserved non-coding sequences (CNSs) at the Foxp3 locus control Foxp3 transcription …