Pathogenesis of depression: insights from human and rodent studies
Major depressive disorder (MDD) will affect one out of every five people in their lifetime and
is the leading cause of disability worldwide. Nevertheless, mechanisms associated with the …
is the leading cause of disability worldwide. Nevertheless, mechanisms associated with the …
The microcosmos of cancer
A Lujambio, SW Lowe - Nature, 2012 - nature.com
The discovery of microRNAs (miRNAs) almost two decades ago established a new
paradigm of gene regulation. During the past ten years these tiny non-coding RNAs have …
paradigm of gene regulation. During the past ten years these tiny non-coding RNAs have …
β-catenin mediates stress resilience through Dicer1/microRNA regulation
Abstract β-catenin is a multi-functional protein that has an important role in the mature
central nervous system; its dysfunction has been implicated in several neuropsychiatric …
central nervous system; its dysfunction has been implicated in several neuropsychiatric …
[HTML][HTML] Epigenetics and microRNAs in cancer
A Ramassone, S Pagotto, A Veronese… - International journal of …, 2018 - mdpi.com
The ability to reprogram the transcriptional circuitry by remodeling the three-dimensional
structure of the genome is exploited by cancer cells to promote tumorigenesis. This …
structure of the genome is exploited by cancer cells to promote tumorigenesis. This …
[HTML][HTML] The crosstalk between microRNAs and the Wnt/β-catenin signaling pathway in cancer
Y Peng, X Zhang, X Feng, X Fan, Z Jin - Oncotarget, 2017 - ncbi.nlm.nih.gov
Mounting evidence has indicated microRNA (miR) dysregulation and the Wnt/β-catenin
signaling pathway jointly drive carcinogenesis, cancer metastasis, and drug-resistance. The …
signaling pathway jointly drive carcinogenesis, cancer metastasis, and drug-resistance. The …
miR-483-5p promotes invasion and metastasis of lung adenocarcinoma by targeting RhoGDI1 and ALCAM
Q Song, Y Xu, C Yang, Z Chen, C Jia, J Chen, Y Zhang… - Cancer research, 2014 - AACR
The nodal regulatory properties of microRNAs (miRNA) in metastatic cancer may offer new
targets for therapeutic control. Here, we report that upregulation of miR-483-5p is correlated …
targets for therapeutic control. Here, we report that upregulation of miR-483-5p is correlated …
[HTML][HTML] Progression to adrenocortical tumorigenesis in mice and humans through insulin-like growth factor 2 and β-catenin
JH Heaton, MA Wood, AC Kim, LO Lima… - The American journal of …, 2012 - Elsevier
Dysregulation of the WNT and insulin-like growth factor 2 (IGF2) signaling pathways has
been implicated in sporadic and syndromic forms of adrenocortical carcinoma (ACC) …
been implicated in sporadic and syndromic forms of adrenocortical carcinoma (ACC) …
microRNA regulation of Wnt signaling pathways in development and disease
JL Song, P Nigam, SS Tektas, E Selva - Cellular signalling, 2015 - Elsevier
Wnt signaling pathways and microRNAs (miRNAs) are critical regulators of development.
Aberrant Wnt signaling pathways and miRNA levels lead to developmental defects and …
Aberrant Wnt signaling pathways and miRNA levels lead to developmental defects and …
[HTML][HTML] Programming of adipose tissue miR-483-3p and GDF-3 expression by maternal diet in type 2 diabetes
D Ferland-McCollough, DS Fernandez-Twinn… - Cell Death & …, 2012 - nature.com
Nutrition during early mammalian development permanently influences health of the adult,
including increasing the risk of type 2 diabetes and coronary heart disease. However, the …
including increasing the risk of type 2 diabetes and coronary heart disease. However, the …
MicroRNA-320a suppresses human colon cancer cell proliferation by directly targeting β-catenin
JY Sun, Y Huang, JP Li, X Zhang, L Wang… - Biochemical and …, 2012 - Elsevier
Recent profile studies of microRNA (miRNA) expression have documented a deregulation of
miRNA (miR-320a) in human colorectal carcinoma. However, its expression pattern and …
miRNA (miR-320a) in human colorectal carcinoma. However, its expression pattern and …