Recent advances in studies of immune memory in mice and humans have reinforced the
concept that memory B cells play a critical role in protection against repeated infections …

Currently approved COVID-19 vaccines administered parenterally induce robust systemic
humoral and cellular responses. While highly effective against severe disease, there is …

Lung-resident memory B cells (MBCs) provide localized protection against reinfection in
respiratory airways. Currently, the biology of these cells remains largely unexplored. Here …

Lung-resident memory B cells (lung-BRMs) differentiate into plasma cells after reinfection,
providing enhanced pulmonary protection. Here, we investigated the determinants of lung …

Epithelial barriers, which include the gastrointestinal, respiratory, and genitourinary mucosa,
compose the body's front line of defense. Since barrier tissues are persistently exposed to …

The nasal mucosa is often the initial site of respiratory viral infection, replication, and
transmission. Understanding how infection shapes tissue-scale primary and memory …

Germinal centers (GCs) form in lymph nodes after immunization or infection to facilitate
antibody affinity maturation and memory and plasma cell (PC) development. PC …

B cells play essential roles in immunity, mainly through the production of high affinity plasma
cells (PCs) and memory B (Bmem) cells. The affinity maturation and differentiation of B cells …

Long-term protective immunity to infectious disease depends on cell-mediated and humoral
immune responses. Induction of a strong humoral response relies on efficient B cell …

Objective The lung is implicated as a site for breach of tolerance prior to onset of
seropositive rheumatoid arthritis (RA). To substantiate this, we investigated lung‐resident B …