Multicomponent reactions with isocyanides

A Dömling, I Ugi - Angewandte Chemie International Edition, 2000 - Wiley Online Library
Multicomponent reactions (MCRs) are fundamentally different from two‐component
reactions in several aspects. Among the MCRs, those with isocyanides have developed into …

Recent advances in the synthesis of hydantoins: the state of the art of a valuable scaffold

L Konnert, F Lamaty, J Martinez, E Colacino - Chemical Reviews, 2017 - ACS Publications
The review highlights the hydantoin syntheses presented from the point of view of the
preparation methods. Novel synthetic routes to various hydantoin structures, the advances …

" Multi-component reactions: emerging chemistry in drug discovery"'from xylocain to crixivan'

C Hulme, V Gore - Current medicinal chemistry, 2003 - ingentaconnect.com
With the recent emergence of combinatorial chemistry and high-speed parallel synthesis for
drug discovery applications, the multi-component reaction (MCR) has seen a resurgence of …

Recent developments in hydantoin chemistry. A review

M Meusel, M Gütschow - Organic preparations and procedures …, 2004 - Taylor & Francis
RECENT DEVELOPMENTS IN HYDANTOIN CHEMISTRY. A REVIEW Page 1 ORGANIC
PREPARATIONS AND PROCEDURES INT., 36 (5). 391-443 (u)o4) RECENT …

Multikomponentenreaktionen mit isocyaniden

A Dömling, I Ugi - Angewandte Chemie, 2000 - Wiley Online Library
Multikomponentenreaktionen (MCRs) unterscheiden sich in mehreren Aspekten
grundlegend von Zweikomponentenreaktionen. Unter den MCRs haben sich solche mit …

Beyond the Ugi reaction: less conventional interactions between isocyanides and iminium species

L El Kaim, L Grimaud - Tetrahedron, 2009 - Elsevier
The history of isocyanide chemistry goes back to the first synthesis of allyl isocyanide by
alkylation of silver cyanide reported by Lieke in 1859. 1 These isomers of cyanides …

The Bucherer–Bergs multicomponent synthesis of hydantoins—excellence in simplicity

M Kalník, P Gabko, M Bella, M Koóš - Molecules, 2021 - mdpi.com
Hydantoins and their hybrids with other molecules represent a very important group of
heterocycles because they exhibit diverse biological and pharmacological activities in …

Sustainable reactions in tunable solvents

CA Eckert, CL Liotta, D Bush, JS Brown… - The Journal of …, 2004 - ACS Publications
There are now available a variety of tunable solvents; these have been used extensively for
extractions and in a variety of materials applications. Our focus has been to apply these …

Emerging molecular diversity from the intra-molecular Ugi reaction: iterative efficiency in medicinal chemistry

C Hulme, J Dietrich - Molecular diversity, 2009 - Springer
This review details a now established area within the isonitrile multi-component reaction
(IMCR) field of study, namely employing bi-functional reagents in the Ugi reaction for the …

Imine-based multicomponent polymerization: Concepts, structural diversity and applications

P Stiernet, A Debuigne - Progress in Polymer Science, 2022 - Elsevier
Multicomponent reactions (MCRs) are remarkable one-pot combinatorial synthetic tools
involving at least three reactants whose nearly all atoms are incorporated in the final …