Shigellosis is a clinical syndrome caused by invasion of the epithelium lining the terminal
ileum, colon, and rectum by Shigella species. Although infections occur globally, and in …

The rapid emergence of antibiotic resistance in pathogenic microbes is becoming an
imminent global public health problem. Local application of antibiotics might be a solution. In …

Whole-genome sequencing (WGS) has been vital for revealing the rapid temporal and
spatial evolution of antimicrobial resistance (AMR) in bacterial pathogens. Some …

Shigella is the leading cause of global diarrheal deaths that currently lacks a licensed
vaccine. Shigellosis drives antimicrobial resistance and leads to economic impact through …

We need to apply novel findings towards sustainable approaches for treating and preventing
Shigella infections. Vaccines and alternative treatments are under development and may …

Shigella sonnei is the emerging pathogen globally, as it is the second common infectious
species of shigellosis (bloody diarrhoea) in low-and middle-income countries (LMICs) and …

Ciprofloxacin, a second generation broad spectrum fluoroquinolone, is active against both
Gram-positive and Gram-negative bacteria. Ciprofloxacin has a high oral bioavailability and …

Abstract Background In urban Australia, the burden of shigellosis is either in returning
travelers from shigellosis-endemic regions or in men who have sex with men (MSM). Here …

The dynamics of antimicrobial resistance (AMR) in developing countries are poorly
understood, especially in community settings, due to a sparsity of data on AMR prevalence …

Shigella spp. are the leading bacterial cause of severe childhood diarrhoea in low-and
middle-income countries (LMICs), are increasingly antimicrobial resistant and have no …