[HTML][HTML] Precision medicine in human heart modeling: perspectives, challenges, and opportunities
Precision medicine is a new frontier in healthcare that uses scientific methods to customize
medical treatment to the individual genes, anatomy, physiology, and lifestyle of each person …
medical treatment to the individual genes, anatomy, physiology, and lifestyle of each person …
Abnormalities in sodium current and calcium homoeostasis as drivers of arrhythmogenesis in hypertrophic cardiomyopathy
R Coppini, L Santini, I Olivotto… - Cardiovascular …, 2020 - academic.oup.com
Hypertrophic cardiomyopathy (HCM) is a common inherited monogenic disease with a
prevalence of 1/500 in the general population, representing an important cause of …
prevalence of 1/500 in the general population, representing an important cause of …
Whole-heart ventricular arrhythmia modeling moving forward: Mechanistic insights and translational applications
Ventricular arrhythmias are the primary cause of sudden cardiac death and one of the
leading causes of mortality worldwide. Whole-heart computational modeling offers a unique …
leading causes of mortality worldwide. Whole-heart computational modeling offers a unique …
[HTML][HTML] Basic research approaches to evaluate cardiac arrhythmia in heart failure and beyond
Patients with heart failure often develop cardiac arrhythmias. The mechanisms and
interrelations linking heart failure and arrhythmias are not fully understood. Historically …
interrelations linking heart failure and arrhythmias are not fully understood. Historically …
Computational modeling of cardiac electrophysiology and arrhythmogenesis: toward clinical translation
The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …
components across multiple spatial (from ion channel to organ) and temporal (from …
[HTML][HTML] Disease progression of hypertrophic cardiomyopathy: modeling using machine learning
M Pičulin, T Smole, B Žunkovič, E Kokalj… - JMIR Medical …, 2022 - medinform.jmir.org
Background: Cardiovascular disorders in general are responsible for 30% of deaths
worldwide. Among them, hypertrophic cardiomyopathy (HCM) is a genetic cardiac disease …
worldwide. Among them, hypertrophic cardiomyopathy (HCM) is a genetic cardiac disease …
Modeling biomechanics in the healthy and diseased heart
The hierarchical construction of the myocardium plays a pivotal role in the biomechanics of
the heart muscle and the resulting flow of blood. In disease, the construction of the heart …
the heart muscle and the resulting flow of blood. In disease, the construction of the heart …
Realizing Personalized Medicine Using In Silico Tools: A Community Effort
L Geris - Personalized Medicine in the Making: Philosophical …, 2022 - Springer
In silico medicine refers to the use of computer modeling and simulation in healthcare, from
prevention over diagnosis to treatment selection and patient follow-up. It is a technology that …
prevention over diagnosis to treatment selection and patient follow-up. It is a technology that …