The current manuscript is the second update of the original Practical Guide, published in
2013 [Heidbuchel et al. European Heart Rhythm Association Practical Guide on the use of …

Direct oral anticoagulants (DOAC s) have quickly become attractive alternatives to the long‐
standing standard of care in anticoagulation, vitamin K antagonist. DOAC s are indicated for …

Two specific reversal agents for direct oral anticoagulants (DOACs) have been approved in
the United States: idarucizumab for dabigatran reversal and andexanet alfa for apixaban …

Importance Patients with atrial fibrillation (AF) who use a direct oral anticoagulant (DOAC)
and request elective surgery or procedure present a common clinical situation yet …

Abstract The Perioperative Anticoagulation Use for Surgery Evaluation (PAUSE) study
prospectively evaluated a prespecified periprocedural-interruption strategy of direct oral …

Irrespective of the reason for hypoperfusion, hypocoagulable and/or hyperfibrinolytic
hemostatic aberrancies afflict up to one-quarter of critically ill patients in shock. Intensivists …

Insertion of venous access devices (VAD) is usually considered a procedure with low risk of
bleeding. Nonetheless, insertion of some devices is invasive enough to be associated with …

Background In the PAUSE (Perioperative Anticoagulant Use for Surgery Evaluation) Study,
a simple, standardized, perioperative interruption strategy was provided for patients with …

Ecarin is derived from venom of Echis carinatus, and will activate prothrombin into
meizothrombin which will then cleave fibrinogen to result in clot formation. Ecarin based …

Background There is an increasing amount of literature on direct oral anticoagulant (DOAC)
laboratory monitoring. The aims of the present review were to evaluate published data on …