The structural biology of galectin-ligand recognition: current advances in modeling tools, protein engineering, and inhibitor design
CP Modenutti, JIB Capurro, S Di Lella… - Frontiers in Chemistry, 2019 - frontiersin.org
Galectins (formerly known as “S-type lectins”) are a subfamily of soluble proteins that
typically bind β-galactoside carbohydrates with high specificity. They are present in many …
typically bind β-galactoside carbohydrates with high specificity. They are present in many …
Galectins and galectin-mediated autophagy regulation: new insights into targeted cancer therapy
D Liu, H Zhu, C Li - Biomarker Research, 2023 - Springer
Galectins are animal lectins with specific affinity for galactosides via the conserved
carbohydrate recognition domains. Increasing studies recently have identified critical roles …
carbohydrate recognition domains. Increasing studies recently have identified critical roles …
Protein crystallization promotes type 2 immunity and is reversible by antibody treatment
EK Persson, K Verstraete, I Heyndrickx, E Gevaert… - Science, 2019 - science.org
INTRODUCTION Spontaneous protein crystallization rarely occurs in vivo. When it does,
crystals are generated, which sustain long-term protein storage or enable the slow release …
crystals are generated, which sustain long-term protein storage or enable the slow release …
Chronic rhinosinusitis with nasal polyposis (CRSwNP): the correlation between expression of Galectin-10 and Clinical-Cytological Grading (CCG)
M Gelardi, GS Netti, R Giancaspro… - American Journal of …, 2022 - journals.sagepub.com
Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is typically characterized by
Type 2 inflammation. Several biomarkers of eosinophilic inflammation, including Galectin …
Type 2 inflammation. Several biomarkers of eosinophilic inflammation, including Galectin …
[HTML][HTML] Therapeutic potential of targeting galectins–A biomaterials-focused perspective
Among all the biological entities involved in the immune response, galectins, a family of
glycan-binding proteins, have been described as key in immune cell homeostasis and …
glycan-binding proteins, have been described as key in immune cell homeostasis and …
A brief history of Charcot-Leyden crystal protein/galectin-10 research
J Su - Molecules, 2018 - mdpi.com
Eosinophils are present in tissues, such as the respiratory tract, spleen, lymph nodes and
blood vessels. The significant presence of eosinophils in these tissues are associated with …
blood vessels. The significant presence of eosinophils in these tissues are associated with …
Galectin functions in cancer-associated inflammation and thrombosis
L Kruk, A Braun, E Cosset, T Gudermann… - Frontiers in …, 2023 - frontiersin.org
Galectins are carbohydrate-binding proteins that regulate many cellular functions including
proliferation, adhesion, migration, and phagocytosis. Increasing experimental and clinical …
proliferation, adhesion, migration, and phagocytosis. Increasing experimental and clinical …
Charcot-Leyden crystal protein/galectin-10 interacts with cationic ribonucleases and is required for eosinophil granulogenesis
MM Grozdanovic, CB Doyle, L Liu, BT Maybruck… - Journal of Allergy and …, 2020 - Elsevier
Background The human eosinophil Charcot-Leyden crystal (CLC) protein is a member of the
Galectin superfamily and is also known as galectin-10 (Gal-10). CLC/Gal-10 forms the …
Galectin superfamily and is also known as galectin-10 (Gal-10). CLC/Gal-10 forms the …
Human galectin-16 has a pseudo ligand binding site and plays a role in regulating c-Rel-mediated lymphocyte activity
Y Si, Y Yao, GJ Ayala, X Li, Q Han, W Zhang… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Background The structure of human galectin-16 (Gal-16) has yet to be solved, and its
function has remained elusive. Methods X-ray crystallography was used to determine the …
function has remained elusive. Methods X-ray crystallography was used to determine the …
[HTML][HTML] Linker remodels human Galectin-8 structure and regulates its hemagglutination and pro-apoptotic activity
Y Si, J Cai, J Zhu, Y Wang, F Zhang, L Meng… - International Journal of …, 2023 - Elsevier
Numerous articles have reported the involvement of linker in regulating bioactivity of tandem-
repeat galectins. We hypothesize that linker interacts with N/C-CRDs to regulate the …
repeat galectins. We hypothesize that linker interacts with N/C-CRDs to regulate the …