Galectins (formerly known as “S-type lectins”) are a subfamily of soluble proteins that
typically bind β-galactoside carbohydrates with high specificity. They are present in many …

Galectins are animal lectins with specific affinity for galactosides via the conserved
carbohydrate recognition domains. Increasing studies recently have identified critical roles …

INTRODUCTION Spontaneous protein crystallization rarely occurs in vivo. When it does,
crystals are generated, which sustain long-term protein storage or enable the slow release …

Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is typically characterized by
Type 2 inflammation. Several biomarkers of eosinophilic inflammation, including Galectin …

Among all the biological entities involved in the immune response, galectins, a family of
glycan-binding proteins, have been described as key in immune cell homeostasis and …

Eosinophils are present in tissues, such as the respiratory tract, spleen, lymph nodes and
blood vessels. The significant presence of eosinophils in these tissues are associated with …

Galectins are carbohydrate-binding proteins that regulate many cellular functions including
proliferation, adhesion, migration, and phagocytosis. Increasing experimental and clinical …

Background The human eosinophil Charcot-Leyden crystal (CLC) protein is a member of the
Galectin superfamily and is also known as galectin-10 (Gal-10). CLC/Gal-10 forms the …

Background The structure of human galectin-16 (Gal-16) has yet to be solved, and its
function has remained elusive. Methods X-ray crystallography was used to determine the …

Numerous articles have reported the involvement of linker in regulating bioactivity of tandem-
repeat galectins. We hypothesize that linker interacts with N/C-CRDs to regulate the …