The role of extracellular structures in Clostridioides difficile biofilm formation

LA Ronish, B Biswas, RM Bauer, ME Jacob… - Anaerobe, 2024 - Elsevier
C. difficile infection (CDI) is a costly and increasing burden on the healthcare systems of
many developed countries due to the high rates of nosocomial infections. Despite the …

Clostridioides difficile-mucus interactions encompass shifts in gene expression, metabolism, and biofilm formation

KL Furtado, L Plott, M Markovetz, D Powers, H Wang… - Msphere, 2024 - Am Soc Microbiol
In a healthy colon, the stratified mucus layer serves as a crucial innate immune barrier to
protect the epithelium from microbes. Mucins are complex glycoproteins that serve as a …

Evaluating the transcriptomic, metabolic, and dynamic responses of Clostridioides difficile to mucus using a novel primary human intestinal epithelial cell and …

KL Furtado Selna - 2024 - cdr.lib.unc.edu
Clostridioides difficile is an urgent public health threat, causing nearly 250,000 hospital-
acquired infections and over 12,000 deaths annually in the United States. C. difficile is also …