Signaling pathways and intervention therapies in sepsis
Y Zhang, B Ning - Signal Transduction and Targeted Therapy, 2021 - nature.com
Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection. Over decades, advanced …
systemic inflammatory and immune response to infection. Over decades, advanced …
DAMPs and NETs in sepsis
Sepsis is a deadly inflammatory syndrome caused by an exaggerated immune response to
infection. Much has been focused on host response to pathogens mediated through the …
infection. Much has been focused on host response to pathogens mediated through the …
Endothelial dysfunction and immunothrombosis in sepsis
E Maneta, E Aivalioti, S Tual-Chalot… - Frontiers in …, 2023 - frontiersin.org
Sepsis is a life-threatening clinical syndrome characterized by multiorgan dysfunction
caused by a dysregulated or over-reactive host response to infection. During sepsis, the …
caused by a dysregulated or over-reactive host response to infection. During sepsis, the …
Coronavirus disease 2019–associated thrombosis and coagulopathy: review of the pathophysiological characteristics and implications for antithrombotic management
L Ortega‐Paz, D Capodanno… - Journal of the …, 2021 - Am Heart Assoc
Abstract Coronavirus disease 2019 (COVID‐19) is an infectious disease caused by severe
acute respiratory syndrome coronavirus‐2, which has posed a significant threat to global …
acute respiratory syndrome coronavirus‐2, which has posed a significant threat to global …
Inflammation in chronic wounds
Non-healing chronic wounds present a major biological, psychological, social, and financial
burden on both individual patients and the broader health system. Pathologically extensive …
burden on both individual patients and the broader health system. Pathologically extensive …
Interleukin-1 receptor blockade is associated with reduced mortality in sepsis patients with features of macrophage activation syndrome: reanalysis of a prior phase III …
B Shakoory, JA Carcillo, WW Chatham… - Critical care …, 2016 - journals.lww.com
Objective: To determine the efficacy of anakinra (recombinant interleukin-1 receptor
antagonist) in improving 28-day survival in sepsis patients with features of macrophage …
antagonist) in improving 28-day survival in sepsis patients with features of macrophage …
Is there new hope for therapeutic matrix metalloproteinase inhibition?
RE Vandenbroucke, C Libert - Nature reviews Drug discovery, 2014 - nature.com
Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that form a family of
24 members in mammals. Evidence of the pathological roles of MMPs in various diseases …
24 members in mammals. Evidence of the pathological roles of MMPs in various diseases …
Coagulopathy and sepsis: Pathophysiology, clinical manifestations and treatment
M Giustozzi, H Ehrlinder, D Bongiovanni, JA Borovac… - Blood reviews, 2021 - Elsevier
Sepsis is a complex syndrome with a high incidence, increasing by 8.7% annually over the
last 20 years. Coagulopathy is a leading factor associated with mortality in patients with …
last 20 years. Coagulopathy is a leading factor associated with mortality in patients with …
How I treat disseminated intravascular coagulation
M Levi, M Scully - Blood, The Journal of the American Society …, 2018 - ashpublications.org
Disseminated intravascular coagulation (DIC) is a condition characterized by systemic
activation of coagulation, potentially leading to thrombotic obstruction of small and midsize …
activation of coagulation, potentially leading to thrombotic obstruction of small and midsize …
Pyroptosis: a pro-inflammatory type of cell death in cardiovascular disease
Q Wang, J Wu, Y Zeng, K Chen, C Wang, S Yang… - Clinica chimica acta, 2020 - Elsevier
Pyroptosis is a pro-inflammatory type of regulated cell death (RCD) characterized by
gasdermin D (GSDMD)-mediated membrane pore formation, cell swelling and rapid lysis …
gasdermin D (GSDMD)-mediated membrane pore formation, cell swelling and rapid lysis …