Cancer risk assessment, indicators, and guidelines for polycyclic aromatic hydrocarbons in the ambient air.

CE Boström, P Gerde, A Hanberg… - Environmental …, 2002 - ehp.niehs.nih.gov
Polycyclic aromatic hydrocarbons (PAHs) are formed during incomplete combustion.
Domestic wood burning and road traffic are the major sources of PAHs in Sweden. In …

Mitochondrial DNA damage and its consequences for mitochondrial gene expression

SD Cline - Biochimica et Biophysica Acta (BBA)-Gene Regulatory …, 2012 - Elsevier
How mitochondria process DNA damage and whether a change in the steady-state level of
mitochondrial DNA damage (mtDNA) contributes to mitochondrial dysfunction are questions …

Differences in the catalytic efficiencies of allelic variants of glutathione transferase P1-1 towards carcinogenic diol epoxides of polycyclic aromatic hydrocarbons.

K Sundberg, AS Johansson, G Stenberg… - …, 1998 - academic.oup.com
Previous studies have identified allelic variants of the human glutathione transferase (GST)
Pi gene and showed that the two different encoded proteins with isoleucine (GSTP1-1/I-105) …

Crystal structure of a benzo[a]pyrene diol epoxide adduct in a ternary complex with a DNA polymerase

H Ling, JM Sayer, BS Plosky, H Yagi… - Proceedings of the …, 2004 - National Acad Sciences
The first occupation-associated cancers to be recognized were the sooty warts (cancers of
the scrotum) suffered by chimney sweeps in 18th century England. In the 19th century, high …

Exposure to polycyclic aromatic hydrocarbons: bulky DNA adducts and cellular responses

F Henkler, K Stolpmann, A Luch - Molecular, Clinical and Environmental …, 2012 - Springer
Environmental and dietary carcinogens such as polycyclic aromatic hydrocarbons (PAHs)
have been intensively studied for decades. Although the genotoxicity of these compounds is …

DNA adducts: biological markers of exposure and potential applications to risk assessment

DK La, JA Swenberg - Mutation Research/Reviews in Genetic Toxicology, 1996 - Elsevier
DNA adducts have been investigated extensively during the past decade. This research has
been advanced, in part, by the development of ultrasensitive analytical methods, such as …

Assessing the impact of Benzo[a]pyrene on Marine Mussels: Application of a novel targeted low density microarray complementing classical biomarker responses

M Banni, S Sforzini, VM Arlt, A Barranger, LJ Dallas… - PloS one, 2017 - journals.plos.org
Despite the increasing use of mussels in environmental monitoring and ecotoxicological
studies, their genomes and gene functions have not been thoroughly explored. Several …

Dibenzo [a, l] pyrene-induced DNA adduction, tumorigenicity, and Ki-ras oncogene mutations in strain A/J mouse lung.

AK Prahalad, JA Ross, GB Nelson, BC Roop… - …, 1997 - academic.oup.com
Abstract Dibenzo [a, l] pyrene (DB [a, l] P), an environmental polycyclic aromatic
hydrocarbon, is the most potent carcinogen ever tested in mouse skin and rat mammary …

Structure of a high fidelity DNA polymerase bound to a benzo [a] pyrene adduct that blocks replication

GW Hsu, X Huang, NP Luneva, NE Geacintov… - Journal of Biological …, 2005 - ASBMB
Of the carcinogens to which humans are most frequently exposed, the polycyclic aromatic
hydrocarbon benzo [a] pyrene (BP) is one of the most ubiquitous. BP is a byproduct of grilled …

Efficiency and accuracy of SOS-induced DNA polymerases replicating benzo [a] pyrene-7, 8-diol 9, 10-epoxide A and G adducts

X Shen, JM Sayer, H Kroth, I Ponten… - Journal of Biological …, 2002 - ASBMB
Nucleotide incorporation fidelity, mismatch extension, and translesion DNA synthesis
efficiencies were determined using SOS-induced Escherichia coli DNA polymerases (pol) II …