The WNT–β-catenin system is an evolutionary conserved signalling pathway that is of
particular importance for morphogenesis and cell organization during embryogenesis. The …

Low bone mass and strength lead to fragility fractures, for example, in elderly individuals
affected by osteoporosis or children with osteogenesis imperfecta. A decade ago, rare …

Controlling the excessive fracture burden in patients with chronic kidney disease (CKD)
Stages G4–G5D remains an impressive challenge. The reasons are 2-fold. First, the …

In addition to its structural role, the skeleton serves as an endocrine organ that controls
mineral metabolism and energy homeostasis. Three major cell types in bone-osteoblasts …

The link between vascular calcification (VC) and increased mortality is now well established.
Over time, as clinical importance of this phenomenon has begun to be fully considered …

The causes of excess cardiovascular mortality associated with chronic kidney disease
(CKD) have been attributed in part to the CKD-mineral bone disorder syndrome (CKD-MBD) …

Wnt signaling affects both bone modeling, which occurs during development, and bone
remodeling, which is a lifelong process involving tissue renewal. Wnt signals are especially …

It is commonly held that osteitis fibrosa and mixed uremic osteodystrophy are the
predominant forms of renal osteodystrophy in patients with chronic kidney disease. Osteitis …

In the course of chronic kidney disease (CKD), alterations in the bone-vascular axis
augment the risk of bone loss, fractures, vascular and soft tissue calcification, left ventricular …

The chronic kidney disease–mineral and bone disorder (CKD–MBD) syndrome is an
extremely important complication of kidney diseases. Here we tested whether CKD–MBD …