Abstract Carboxylesterases (CES1 and CES2) and arylacetamide deacetylase (AADAC),
which are expressed primarily in the liver and/or gastrointestinal tract, hydrolyze drugs …

Background Although many experiments and clinical studies have proved the link between
the expression of CDKN3 and human tumors, we have not been able to identify any …

Combining omics data from different layers using integrative methods provides a better
understanding of the biology of a complex disease such as cancer. The discovery of …

Summary The PIP 3/PI3K network is a central regulator of metabolism and is frequently
activated in cancer, commonly by loss of the PIP 3/PI (3, 4) P 2 phosphatase, PTEN. Despite …

Background Cyclin-dependent kinase inhibitor 3 (CDKN3) has been studied in many
cancers. However, the comprehensive and systematic pancancer analysis of CDKN3 genes …

Lung adenocarcinoma (LUAD) is a malignant tumor of the respiratory system that has a poor
5-year survival rate. Anoikis, a type of programmed cell death, contributes to tumor …

We conducted a high-content screening (HCS) in neuroblastoma BE (2)-C cells to identify
cell cycle regulators that control cell differentiation using a library of siRNAs against cell …

Background Ankyrin repeat domain 53 (ANKRD53) plays an important role in maintaining
chromosome integrity and stability, and chromosome instability is associated with cancer …

Background Cell cycle protein-dependent kinase inhibitor protein 3 (CDKN3), as a member
of the protein kinase family, has been demonstrated to exhibit oncogenic properties in …

Background Arylacetamide deacetylase (AADAC) is a lipolytic enzyme involved in
xenobiotic metabolism. The characterization in terms of activity and substrate preference has …