Osteoarthritis comprises several joint disorders characterized by articular cartilage
degeneration and persistent pain, causing disability and economic burden. The incidence of …

Neuropathic pain is caused by a lesion or disease of the somatosensory system, including
peripheral fibres (Aβ, Aδ and C fibres) and central neurons, and affects 7–10% of the …

Different neuroplastic processes can occur along the nociceptive pathways and may be
important in the transition from acute to chronic pain and for diagnosis and development of …

The redefinition of neuropathic pain, 23 which specifically excludes the concept of
“dysfunction,” has left a large group of patients without a valid pathophysiological descriptor …

A systematic literature review was undertaken to determine if conditioned pain modulation
(CPM) is reliable. Longitudinal, English language observational studies of the repeatability …

Fibromyalgia is a common illness characterized by chronic widespread pain, sleep
problems (including unrefreshing sleep), physical exhaustion and cognitive difficulties. The …

Background Several studies have identified clinical, psychosocial, patient characteristic, and
perioperative variables that are associated with persistent postsurgical pain; however, the …

Objective Emerging evidence suggests that pain sensitization plays an important role in pain
associated with knee osteoarthritis (OA). This systematic review and meta-analysis …

Abstract Development and application of psychophysical test paradigms to assess
endogenous pain modulation in healthy controls and in patients yielded large body of data …

Pain due to osteoarthritis (OA) is one of the most frequent causes of chronic pain. However,
the mechanisms of OA pain are poorly understood. This review addresses the mechanisms …