Anticancer activity of Mannich bases: a review of recent literature
G Roman - ChemMedChem, 2022 - Wiley Online Library
This report summarizes the latest published data on the antiproliferative action and cytotoxic
activity of Mannich bases, a structurally heterogeneous category of chemical entities that …
activity of Mannich bases, a structurally heterogeneous category of chemical entities that …
Discovery of indolinone-bearing benzenesulfonamides as new dual carbonic anhydrase and VEGFR-2 inhibitors possessing anticancer and pro-apoptotic properties
In the current medical era, the utilization of a single small molecule to simultaneously target
two distinct molecular targets is emerging as a highly effective strategy in the battle against …
two distinct molecular targets is emerging as a highly effective strategy in the battle against …
Design and synthesis of 6-arylpyridine-tethered sulfonamides as novel selective inhibitors of carbonic anhydrase IX with promising antitumor features toward the …
Hypoxia, a characteristic feature of solid tumors, develops as a result of excessive cell
proliferation and rapid tumor growth exceeding the oxygen supply, and can result in …
proliferation and rapid tumor growth exceeding the oxygen supply, and can result in …
Discovery of 4-alkoxy-2-aryl-6, 7-dimethoxyquinolines as a new class of topoisomerase I inhibitors endowed with potent in vitro anticancer activity
In our attempt to develop potential anticancer agents targeting Topoisomerase I (TOP1), two
novel series of 4-alkoxy-2-arylquinolines 14a-p and 19a-c were designed and synthesized …
novel series of 4-alkoxy-2-arylquinolines 14a-p and 19a-c were designed and synthesized …
2-Arylquinolines as novel anticancer agents with dual EGFR/FAK kinase inhibitory activity: synthesis, biological evaluation, and molecular modelling insights
MM Elbadawi, WM Eldehna… - Journal of Enzyme …, 2022 - Taylor & Francis
In this study, different assortments of 2-arylquinolines and 2, 6-diarylquinolines have been
developed. Recently, we have developed a new series of 6, 7-dimethoxy-4-alkoxy-2 …
developed. Recently, we have developed a new series of 6, 7-dimethoxy-4-alkoxy-2 …
Thiohydantoin derivatives incorporating a pyrazole core: Design, synthesis and biological evaluation as dual inhibitors of topoisomerase-I and cycloxygenase-2 with …
A new series of hybrid structures 14a–l containing thiohydantoin as anti-cancer moiety and
pyrazole core possessing SO 2 Me pharmacophore as selective COX-2 moiety was …
pyrazole core possessing SO 2 Me pharmacophore as selective COX-2 moiety was …
Synthesis, anti-cancer activity, gene expression and docking stimulation of 2-thioxoimidazolidin-4-one derivatives
GH Elsayed, AM Fahim, AI Khodair - Journal of Molecular Structure, 2022 - Elsevier
In this elucidation, we synthesized different 2-thioxoimidazolidin-4-one derivatives through
the condensation of N-methyl glycine (1) with various alkyl isothiocyanates 2 in refluxing …
the condensation of N-methyl glycine (1) with various alkyl isothiocyanates 2 in refluxing …
Synthesis, antiviral, DFT and molecular docking studies of some novel 1, 2, 4-triazine nucleosides as potential bioactive compounds
A novel series of nucleosides with potential antiviral activity have been synthesized and
characterized using IR, MS, 1D NMR and 2D NMR data. The antiviral activity of the …
characterized using IR, MS, 1D NMR and 2D NMR data. The antiviral activity of the …
New bis-hydantoin/thiohydantoin derivatives: Regioselective synthesis, antibacterial activity, molecular docking, and computational insights
AI Khodair, AI Metwally, NA Kheder… - Journal of Molecular …, 2024 - Elsevier
Concerning the reported biological activities of bis-heterocycles, hydantoin, and
thiohydantoin moieties, a series of some new bis-hydantoins/thiohydantoins have been …
thiohydantoin moieties, a series of some new bis-hydantoins/thiohydantoins have been …
Design, synthesis and biological evaluation of novel thiohydantoin derivatives as antiproliferative agents: A combined experimental and theoretical assessments
In our endeavors to develop potent anticancer agents, novel two series of 3, 5-disubstituted-
2-thiohydantoins 5a–c and the S-methyl counterparts 6a–c were designed and synthesized …
2-thiohydantoins 5a–c and the S-methyl counterparts 6a–c were designed and synthesized …