Cell culture is a widely used in vitro tool for improving our understanding of cell biology,
tissue morphology, and mechanisms of diseases, drug action, protein production and the …

Abstract cGMP controls many cellular functions ranging from growth, viability, and
differentiation to contractility, secretion, and ion transport. The mammalian genome encodes …

Dynamic aspects of interactions between astrocytes, neurons and the vasculature have
recently been in the neuroscience spotlight. It has emerged that not only neurons but also …

Abstract Inositol 1, 4, 5-trisphosphate is a second messenger which regulates intracellular
calcium both by mobilizing calcium from internal stores and, perhaps indirectly, by …

Sáez, Juan C., Viviana M. Berthoud, María C. Brañes, Agustín D. Martínez, and Eric C.
Beyer. Plasma Membrane Channels Formed by Connexins: Their Regulation and Functions …

Connexin 43 (Cx43) gap junctions and hemichannels mediate astrocyte intercellular
communication in the central nervous system under normal conditions and contribute to …

Gap junctions are plasma membrane spatial microdomains constructed of assemblies of
channel proteins called connexins in vertebrates and innexins in invertebrates. The …

Adjacent cells share ions, second messengers and small metabotes through intercellular
channels which are present in gap junctions. This type of intercellular communication …

Gap junctions allow the exchange of ions, second messengers, and small metabolites
between adjacent cells and are formed by two unrelated protein families, the pannexins and …

Gap junctions consist of intercellular channels that connect the cytoplasm of adjacent cells
directly and allow the exchange of small molecules. These channels are unique in that they …