Recombinant proteins are the mainstay of biopharmaceuticals. A key challenge in the
manufacturing and formulation of protein biologic products is the tendency for the active …

Conjugation of various reagents to antibodies has long been an elegant way to combine the
superior binding features of the antibody with other desired but non-natural functions …

In this study, we demonstrated the first, to our knowledge, integrated continuous bioprocess
(ICB) designed for the production of acid‐sensitive monoclonal antibodies, prone to …

Monoclonal antibodies (mAbs) have been served as 'magic bullet'to treat autoimmune
diseases, cancers, and infectious diseases. Due to the complexity of biological sample and …

Monoclonal antibodies (mAb) are used as therapeutics and for diagnostics of a variety of
diseases, and novel antibodies are continuously being developed to find treatments for new …

Protein A chromatography is one of the most widely used purification steps in the
manufacturing of the various classes of recombinant and non-recombinant antibodies. Due …

Designing proteins with tunable activities from easily accessible external cues remains a
biotechnological challenge. Here, we set out to create a small antibody-binding domain …

The manufacturability of therapeutic monoclonal antibodies is limited by the harsh
conditions that antibodies are subjected to during the purification procedure, which in turn …

Antibody–drug conjugates (ADCs) have demonstrated great therapeutic potential due to
their ability to target the delivery of potent cytotoxins. However, the heterogeneous nature of …

The reversible interaction between an affinity ligand and a complementary receptor has
been widely explored in purification systems for several biomolecules. The development of …