Ruthenium (II) complex cis-[RuII2-O2CC7H7O2)(dppm)2]PF6-hmxbato induces ROS-mediated apoptosis in lung tumor cells producing selective …

MS Costa, YG Gonçalves, BC Borges, MJB Silva… - Scientific Reports, 2020 - nature.com
Ruthenium complexes have been extensively explored as potential molecules for cancer
treatment. Considering our previous findings on the remarkable cytotoxic activity exhibited …

Nanoencapsulation of a ruthenium (ii) complex with triazolopyrimidine in liposomes as a tool for improving its anticancer activity against melanoma cell lines

M Fandzloch, A Jaromin, M Zaremba-Czogalla… - Dalton …, 2020 - pubs.rsc.org
Two types of ruthenium (II) complexes containing 1, 2, 4-triazolo [1, 5-a] pyrimidines of the
general formulas [RuCl2 (dmso) 3 (L)]((1)–(3)) and [RuCl2 (dmso) 2 (L) 2]((4)–(6)), where L …

Multiplatform metabolomics studies of human cancers with NMR and mass spectrometry imaging

AB Zhong, IH Muti, SJ Eyles, RW Vachet… - Frontiers in Molecular …, 2022 - frontiersin.org
The status of metabolomics as a scientific branch has evolved from proof-of-concept to
applications in science, particularly in medical research. To comprehensively evaluate …

Syntheses, characterization, DNA/HSA binding ability and antitumor activities of a family of isostructural binuclear lanthanide complexes containing hydrazine Schiff …

XQ Song, ZG Wang, Y Wang, YY Huang… - Journal of …, 2020 - Taylor & Francis
Three dinuclear lanthanide complexes,[Ln2 (L) 2 (μ3-OAc) 4 (H2O) 2]⋅ 2H2O (Ln= La (1),
Eu (2) and Dy (3), HL= N'-(2-hydroxybenzylidene) nicotinohydrazide), have been …

Cytotoxicity of ruthenium-N, N-disubstituted-N′-acylthioureas complexes

TD de Oliveira, AM Plutín, L Luna-Dulcey… - Materials Science and …, 2020 - Elsevier
Five new complexes with general formula [Ru (L n)(Psingle bondP)(bipy)] PF 6, where L n=
N, N′-dimethyl-N-Acyl thiourea, and PP: 1, 2-bis (diphenylphosphino) ethane (dppe) or 1, 4 …

Synthesis, characterization and in vitro cytotoxicity of ruthenium (II) metronidazole complexes: Cell cycle arrest at G1/S transition and apoptosis induction in MCF-7 …

CC Candido, HVR Silva, B Zavan, M Ionta… - Journal of Inorganic …, 2022 - Elsevier
Ruthenium compounds are known to be potential drug candidates since they offer the
potential for reduced toxicity. Furthermore, the various oxidation states, different …

Ruthenium (II) complex containing cinnamic acid derivative inhibits cell cycle progression at G0/G1 and induces apoptosis in melanoma cells

AA Negreti, GA Ferreira-Silva, CG Pressete… - New Journal of …, 2022 - pubs.rsc.org
Melanoma is a highly aggressive skin cancer with a limited targeted therapy arsenal.
Ruthenium-based complexes have shown interesting pro-apoptotic effects on malignant …

Cyto-genotoxic evaluation of novel anti-tubercular copper (II) complexes containing isoniazid-based ligands

NF Fregonezi, FA de Souza, NA Aleixo… - Regulatory toxicology …, 2020 - Elsevier
Considering the promising previous results of Cu (II) complexes with isoniazid active ligand
against Mycobacterium tuberculosis, the main causative agent of tuberculosis, novel …

Novel ruthenium (III) complexes with hydroxybenzophenones: experimental and theoretical characterization and in vitro leishmanicidal activity comparing complexes …

JSM Dias, FT Martins, JH de Araujo Neto… - New Journal of …, 2021 - pubs.rsc.org
In this study, novel ruthenium (III) complexes with hydroxybenzophenones with the general
formula cis-[RuCl2 (HB)(dppb)] were obtained, where HB= 2-hydroxy-4-(octyloxy) …

Novel ruthenium (II) complexes with cimetidine: DFT calculations and in vitro cytotoxic activities against glioblastoma cell lines

JSM Dias, HVR Silva, CC Candido, GÁF da Silva… - Inorganica Chimica …, 2020 - Elsevier
Herein, four novel ruthenium (II) complexes containing cimetidine as a ligand were
obtained,[RuCl (CIM)(dppb)(bipy)] Cl (1),[RuCl (CIM)(dppb)(4, 4′-Me-bipy)] Cl (2),[RuCl …