The mucosal immune system and IgA nephropathy

L Gesualdo, V Di Leo, R Coppo - Seminars in immunopathology, 2021 - Springer
The precise pathogenesis of immunoglobulin A nephropathy (IgAN) is still not clearly
established but emerging evidence confirms a pivotal role for mucosal immunity. This review …

[HTML][HTML] New developments in the genetics, pathogenesis, and therapy of IgA nephropathy

R Magistroni, VD D'Agati, GB Appel, K Kiryluk - Kidney international, 2015 - Elsevier
Recent years have brought notable progress in the field of IgA nephropathy. Here, we
highlight important new directions and latest developments, including successful discovery …

Genome-wide association study identifies susceptibility loci for IgA nephropathy

AG Gharavi, K Kiryluk, M Choi, Y Li, P Hou, J Xie… - Nature …, 2011 - nature.com
We carried out a genome-wide association study of IgA nephropathy, a major cause of
kidney failure worldwide. We studied 1,194 cases and 902 controls of Chinese Han …

Geographic differences in genetic susceptibility to IgA nephropathy: GWAS replication study and geospatial risk analysis

K Kiryluk, Y Li, S Sanna-Cherchi… - PLoS …, 2012 - journals.plos.org
IgA nephropathy (IgAN), major cause of kidney failure worldwide, is common in Asians,
moderately prevalent in Europeans, and rare in Africans. It is not known if these differences …

IgA nephropathy

JV Donadio, JP Grande - New England Journal of Medicine, 2002 - Mass Medical Soc
IgA nephropathy is the most common form of primary glomerulonephritis in the world and is
also the most common cause of end-stage renal disease in patients with primary …

The emerging role of complement proteins as a target for therapy of IgA nephropathy

DV Rizk, N Maillard, BA Julian, B Knoppova… - Frontiers in …, 2019 - frontiersin.org
IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide
and a common cause of end-stage renal disease. Evaluation of a kidney biopsy is …

The Tn antigen—structural simplicity and biological complexity

T Ju, VI Otto, RD Cummings - … Chemie International Edition, 2011 - Wiley Online Library
Glycoproteins in animal cells contain a variety of glycan structures that are added co‐and/or
posttranslationally to proteins. Of over 20 different types of sugar–amino acid linkages …

Natural history of idiopathic IgA nephropathy and factors predictive of disease outcome

G D'Amico - Seminars in nephrology, 2004 - Elsevier
Among the numerous studies published in the last 20 years that have calculated the
actuarial renal survival and tried to individuate the prognostic role of the clinical and …

Multiplexed genotyping with sequence-tagged molecular inversion probes

P Hardenbol, J Banér, M Jain, M Nilsson… - Nature …, 2003 - nature.com
We report on the development of molecular inversion probe (MIP) genotyping, an efficient
technology for large-scale single nucleotide polymorphism (SNP) analysis. This technique …

A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy

XQ Yu, M Li, H Zhang, HQ Low, X Wei, JQ Wang… - Nature …, 2012 - nature.com
We performed a two-stage genome-wide association study of IgA nephropathy (IgAN) in
Han Chinese, with 1,434 affected individuals (cases) and 4,270 controls in the discovery …