Diabetes is a complex metabolic disorder affecting the glucose status of the human body.
Chronic hyperglycaemia related to diabetes is associated with end organ failure. The clinical …

Despite its position as the first-line drug for treatment of type 2 diabetes mellitus, the
mechanisms underlying the plasma glucose level-lowering effects of metformin (1, 1 …

Activating transcription factor 3 (ATF3) is a stress-induced transcription factor that plays vital
roles in modulating metabolism, immunity, and oncogenesis. ATF3 acts as a hub of the …

Metformin is one of the most widely prescribed hypoglycemic drugs and has the potential to
treat many diseases. More and more evidence shows that metformin can regulate the …

Obesity is reported to be a chronic low-grade inflammatory state. Adipose tissue
macrophages play a key role in obesity-related inflammation. Metformin, the most widely …

Metformin is a biguanide drug widely used as the initial treatment of type 2 diabetes. Despite
its widespread use, its precise mechanisms of action remain incompletely characterised. Its …

Background: Skin wound healing is a challenging problem, especially in aging or diabetic
patients, which becomes more difficult to heal, and easily results in considerable public …

With an increasing global burden of coronary artery disease (CAD), early detection and
timely management of risk factors are crucial to reduce morbidity and mortality in such …

Background Metformin, the eldest and most widely used glucose lowering drug, is likely to
be effective also on cardiac and vascular disease prevention. Nonetheless, uncertainty still …

Metformin (dimethyl biguanide) is a synthetic derivative of guanidine, isolated from the
extracts of Galega officinalis, a plant with a prominent antidiabetic effect. Since its discovery …