The use of chitosan, alginate, and pectin in the biomedical and food sector—biocompatibility, bioadhesiveness, and biodegradability

GA Martău, M Mihai, DC Vodnar - Polymers, 2019 - mdpi.com
Nowadays, biopolymers as intelligent and active biopolymer systems in the food and
pharmaceutical industry are of considerable interest in their use. With this association in …

Chitosan and its derivatives for application in mucoadhesive drug delivery systems

TM M. Ways, WM Lau, VV Khutoryanskiy - Polymers, 2018 - mdpi.com
Mucoadhesive drug delivery systems are desirable as they can increase the residence time
of drugs at the site of absorption/action, provide sustained drug release and minimize the …

Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs

M Agrawal, S Saraf, S Saraf, SG Antimisiaris… - Journal of controlled …, 2018 - Elsevier
Abstract According to the Alzheimer Association Report (2017), Alzheimer's disease (AD) is
the 6th primary cause of death in the USA, which affects nearly 5.5 million people. In the …

[HTML][HTML] Physicochemical properties of mucus and their impact on transmucosal drug delivery

J Leal, HDC Smyth, D Ghosh - International journal of pharmaceutics, 2017 - Elsevier
Mucus is a selective barrier to particles and molecules, preventing penetration to the
epithelial surface of mucosal tissues. Significant advances in transmucosal drug delivery …

Natural polysaccharide nanomaterials: an overview of their immunological properties

FG Torres, OP Troncoso, A Pisani, F Gatto… - International journal of …, 2019 - mdpi.com
Natural occurring polymers, or biopolymers, represent a huge part of our planet biomass.
They are formed by long chains of monomers of the same type or a combination of different …

Chitosan—A versatile semi-synthetic polymer in biomedical applications

M Dash, F Chiellini, RM Ottenbrite, E Chiellini - Progress in polymer science, 2011 - Elsevier
This review outlines the new developments on chitosan-based bioapplications. Over the last
decade, functional biomaterials research has developed new drug delivery systems and …

Biodegradation, biodistribution and toxicity of chitosan

T Kean, M Thanou - Advanced drug delivery reviews, 2010 - Elsevier
Chitosan is a natural polysaccharide that has attracted significant scientific interest during
the last two decades. It is a potentially biologically compatible material that is chemically …

Chitosan in nasal delivery systems for therapeutic drugs

L Casettari, L Illum - Journal of Controlled Release, 2014 - Elsevier
There is an obvious need for efficient and safe nasal absorption enhancers for the
development of therapeutically efficacious nasal products for small hydrophilic drugs …

Functional characterization of chitin and chitosan

I Aranaz, M Mengíbar, R Harris, I Paños… - Current chemical …, 2009 - ingentaconnect.com
Chitin and its deacetylated derivative chitosan are natural polymers composed of randomly
distributed β-(1-4)-linked D-glucosamine (deacetylated unit) and N-acetyl-D-glucosamine …

Chitosan chemistry and pharmaceutical perspectives

MNVR Kumar, RAA Muzzarelli, C Muzzarelli… - Chemical …, 2004 - ACS Publications
In the chitin bibliography, a major reference is the book written by Richards in 1951
“primarily for entomologists and other invertebrate zoologists” but also, in the author's hope …