The primary adrenal cortical steroid hormones, aldosterone, and the glucocorticoids cortisol
and corticosterone, act through the structurally similar mineralocorticoid (MR) and …

Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the global obesity
and metabolic disease epidemic and is rapidly becoming the leading cause of liver cirrhosis …

Numerous clinical studies associate an adverse prenatal environment with the development
of cardio-metabolic disorders and neuroendocrine dysfunction, as well as an increased risk …

Glucocorticoids (GCs) are critical regulators of energy balance. Their deregulation is
associated with the development of obesity and metabolic syndrome. However, it is not …

An imbalance between central glucocorticoid (GR) and mineralocorticoid (MR) receptors is
proposed to underlie the HPA axis dysregulation that associates with susceptibility to …

Adverse environments during the fetal and neonatal development period may permanently
program physiology and metabolism, and lead to increased risk of diseases in later life …

Glucocorticoids are vital for the structural and functional maturation of foetal organs, yet
excessive foetal exposure is detrimental to adult cardiovascular health. To elucidate the role …

Glucocorticoids are universally used in the treatment of acute lymphoblastic leukemia (ALL),
and resistance to glucocorticoids in leukemia cells confers poor prognosis. To elucidate …

Glucocorticoids (GC), such as cortisol or dexamethasone, control various physiological
functions, notably those involved in development, metabolism, inflammatory processes and …

Since the discovery of the beneficial effects of adrenocortical extracts for treating adrenal
insufficiency more than 80 years ago, glucocorticoids and their cognate, intracellular …