X-chromosome inactivation (XCI) is the epigenetic mechanism that ensures X-linked dosage
compensation between cells of females (XX karyotype) and males (XY). XCI is essential for …

Advances in RNA-sequencing techniques have led to the discovery of thousands of non-
coding transcripts with unknown function. There are several types of non-coding linear …

In recent years, long noncoding RNAs (lncRNAs) have emerged as an important class of
regulators of gene expression. lncRNAs exhibit several distinctive features that confer …

Genes on the mammalian X chromosome are present in one copy in males and two copies
in females. The complex mechanisms that regulate the X chromosome lead to evolutionary …

X-chromosome inactivation (XCI) balances gene expression between the sexes in female
mammals. Shortly after fertilization, upregulation of Xist RNA from one X chromosome …

In female mammals, one of the two X chromosomes in each cell is transcriptionally silenced
in order to achieve dosage compensation between the genders in a process called X …

The cellular plasticity of pluripotent stem cells is thought to be sustained by genomic regions
that display both active and repressive chromatin properties. These regions exhibit low …

X-chromosome inactivation (XCI) is a developmentally associated process that evolved in
mammals to enable gene dosage compensation between XX and XY individuals. In …

In female eutherian mammals, dosage compensation of X-linked gene expression is
achieved during development through transcriptional silencing of one of the two X …

Long noncoding RNAs (lncRNAs) dysregulated in cancer potentially play oncogenic or
tumor-suppressive roles. While the X inactivate-specific transcript (Xist) lncRNA is important …