Our knowledge of pluripotent stem cell (PSC) biology has advanced to the point where we
now can generate most cells of the human body in the laboratory. PSC-derived …

The discovery of human pluripotent stem cells (hPSCs), including both human embryonic
stem cells and human-induced pluripotent stem cells, has opened up novel paths for a wide …

Rationale: One goal of cardiac tissue engineering is the generation of a living, human pump
in vitro that could replace animal models and eventually serve as an in vivo therapeutic …

Background: Tissue engineering enables the generation of functional human cardiac tissue
with cells derived in vitro in combination with biocompatible materials. Human-induced …

Despite preclinical studies demonstrating the functional benefit of transplanting human
pluripotent stem cell-derived cardiomyocytes (PSC-CMs) into damaged myocardium, the …

The prospect of changing the plasticity of terminally differentiated cells toward pluripotency
has completely altered the outlook for biomedical research. Human-induced pluripotent …

Aging can be seen as process characterized by accumulation of oxidative stress induced
damage. Oxidative stress derives from different endogenous and exogenous processes, all …

Purpose: Both cardiomyocytes and cardiac fibroblasts (CF) play essential roles in cardiac
development, function, and remodeling. Properties of 3D co-cultures are incompletely …

Induced pluripotent stem cells (iPSCs) offer an unprece-dented opportunity to study human
physiology and disease at the cellular level. They also have the potential to be leveraged in …

Current methods to differentiate cardiomyocytes from human pluripotent stem cells (PSCs)
inadequately recapitulate complete development and result in PSC-derived cardiomyocytes …