Mesenchymal stromal cell homing: mechanisms and strategies for improvement
Mesenchymal stromal cells (MSCs) have been widely investigated for their therapeutic
potential in regenerative medicine, owing to their ability to home damaged tissue and serve …
potential in regenerative medicine, owing to their ability to home damaged tissue and serve …
Biological roles of glycans
A Varki - Glycobiology, 2017 - academic.oup.com
Simple and complex carbohydrates (glycans) have long been known to play major
metabolic, structural and physical roles in biological systems. Targeted microbial binding to …
metabolic, structural and physical roles in biological systems. Targeted microbial binding to …
Genetically engineered and enucleated human mesenchymal stromal cells for the targeted delivery of therapeutics to diseased tissue
H Wang, CN Alarcón, B Liu, F Watson… - Nature biomedical …, 2022 - nature.com
Targeting the delivery of therapeutics specifically to diseased tissue enhances their efficacy
and decreases their side effects. Here we show that mesenchymal stromal cells with their …
and decreases their side effects. Here we show that mesenchymal stromal cells with their …
Engineering cell membrane‐based nanotherapeutics to target inflammation
Inflammation is ubiquitous in the body, triggering desirable immune response to defend
against dangerous signals or instigating undesirable damage to cells and tissues to cause …
against dangerous signals or instigating undesirable damage to cells and tissues to cause …
Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow
S Morikawa, Y Mabuchi, Y Kubota, Y Nagai… - Journal of Experimental …, 2009 - rupress.org
Mesenchymal stem cells (MSCs) are defined as cells that undergo sustained in vitro growth
and can give rise to multiple mesenchymal lineages. Because MSCs have only been …
and can give rise to multiple mesenchymal lineages. Because MSCs have only been …
Mesenchymal stem cells: mechanisms of immunomodulation and homing
H Yagi, A Soto-Gutierrez, B Parekkadan… - Cell …, 2010 - journals.sagepub.com
Mesenchymal stem cell (MSC) transplantation has been explored as a new clinical
approach to repair injured tissue. A growing corpus of studies have highlighted two …
approach to repair injured tissue. A growing corpus of studies have highlighted two …
[HTML][HTML] T-lymphocyte homing: an underappreciated yet critical hurdle for successful cancer immunotherapy
R Sackstein, T Schatton, SR Barthel - Laboratory investigation, 2017 - Elsevier
Advances in cancer immunotherapy have offered new hope for patients with metastatic
disease. This unfolding success story has been exemplified by a growing arsenal of novel …
disease. This unfolding success story has been exemplified by a growing arsenal of novel …
Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone
The capacity to direct migration ('homing') of blood-borne cells to a predetermined anatomic
compartment is vital to stem cell–based tissue engineering and other adoptive cellular …
compartment is vital to stem cell–based tissue engineering and other adoptive cellular …
Immune cell infiltration and tertiary lymphoid structures as determinants of antitumor immunity
VH Engelhard, AB Rodriguez, IS Mauldin… - The Journal of …, 2018 - journals.aai.org
Limited representation of intratumoral immune cells is a major barrier to tumor control.
However, simply enhancing immune responses in tumor-draining lymph nodes or through …
However, simply enhancing immune responses in tumor-draining lymph nodes or through …
Targeting selectins and selectin ligands in inflammation and cancer
SR Barthel, JD Gavino, L Descheny… - Expert opinion on …, 2007 - Taylor & Francis
Inflammation and cancer metastasis are associated with extravasation of leukocytes or
tumor cells from blood into tissue. Such movement is believed to follow a coordinated and …
tumor cells from blood into tissue. Such movement is believed to follow a coordinated and …