Mesenchymal stromal cell homing: mechanisms and strategies for improvement

M Ullah, DD Liu, AS Thakor - Iscience, 2019 - cell.com
Mesenchymal stromal cells (MSCs) have been widely investigated for their therapeutic
potential in regenerative medicine, owing to their ability to home damaged tissue and serve …

Biological roles of glycans

A Varki - Glycobiology, 2017 - academic.oup.com
Simple and complex carbohydrates (glycans) have long been known to play major
metabolic, structural and physical roles in biological systems. Targeted microbial binding to …

Genetically engineered and enucleated human mesenchymal stromal cells for the targeted delivery of therapeutics to diseased tissue

H Wang, CN Alarcón, B Liu, F Watson… - Nature biomedical …, 2022 - nature.com
Targeting the delivery of therapeutics specifically to diseased tissue enhances their efficacy
and decreases their side effects. Here we show that mesenchymal stromal cells with their …

Engineering cell membrane‐based nanotherapeutics to target inflammation

H Yan, D Shao, YH Lao, M Li, H Hu… - Advanced …, 2019 - Wiley Online Library
Inflammation is ubiquitous in the body, triggering desirable immune response to defend
against dangerous signals or instigating undesirable damage to cells and tissues to cause …

Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow

S Morikawa, Y Mabuchi, Y Kubota, Y Nagai… - Journal of Experimental …, 2009 - rupress.org
Mesenchymal stem cells (MSCs) are defined as cells that undergo sustained in vitro growth
and can give rise to multiple mesenchymal lineages. Because MSCs have only been …

Mesenchymal stem cells: mechanisms of immunomodulation and homing

H Yagi, A Soto-Gutierrez, B Parekkadan… - Cell …, 2010 - journals.sagepub.com
Mesenchymal stem cell (MSC) transplantation has been explored as a new clinical
approach to repair injured tissue. A growing corpus of studies have highlighted two …

[HTML][HTML] T-lymphocyte homing: an underappreciated yet critical hurdle for successful cancer immunotherapy

R Sackstein, T Schatton, SR Barthel - Laboratory investigation, 2017 - Elsevier
Advances in cancer immunotherapy have offered new hope for patients with metastatic
disease. This unfolding success story has been exemplified by a growing arsenal of novel …

Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone

R Sackstein, JS Merzaban, DW Cain, NM Dagia… - Nature medicine, 2008 - nature.com
The capacity to direct migration ('homing') of blood-borne cells to a predetermined anatomic
compartment is vital to stem cell–based tissue engineering and other adoptive cellular …

Immune cell infiltration and tertiary lymphoid structures as determinants of antitumor immunity

VH Engelhard, AB Rodriguez, IS Mauldin… - The Journal of …, 2018 - journals.aai.org
Limited representation of intratumoral immune cells is a major barrier to tumor control.
However, simply enhancing immune responses in tumor-draining lymph nodes or through …

Targeting selectins and selectin ligands in inflammation and cancer

SR Barthel, JD Gavino, L Descheny… - Expert opinion on …, 2007 - Taylor & Francis
Inflammation and cancer metastasis are associated with extravasation of leukocytes or
tumor cells from blood into tissue. Such movement is believed to follow a coordinated and …