We describe a new hypothesis for the development of autism, that it is driven by imbalances
in brain development involving enhanced effects of paternally expressed imprinted genes …

In mammals, most somatic cells contain two copies of each autosomal gene, one inherited
from each parent. When a gene is expressed, both parental alleles are usually transcribed …

In vitro culture of mouse embryos results in loss of imprinting. The aim of the present study
was to examine how two of the techniques commonly used during assisted reproduction …

Identifying loci with parental differences in DNA methylation is key to unraveling parent-of-
origin phenotypes. By conducting a MeDIP-Seq screen in maternal-methylation free …

Background Smchd1 is an epigenetic modifier essential for X chromosome inactivation:
female embryos lacking Smchd1 fail during midgestational development. Male mice are less …

Imprinted genes, which are preferentially expressed from one or other parental chromosome
as a consequence of epigenetic events in the germline, are known to functionally converge …

Mammalian fetal survival and growth are dependent on a well-established and functional
placenta. Although transient, the placenta is the first organ to be formed during pregnancy …

Genomic imprinting is an epigenetic marking of genes in the parental germline that ensures
the stable transmission of monoallelic gene expression patterns in a parent-of-origin-specific …

Prader-Willi syndrome (PWS) is a neurogenetic multifactorial disorder caused by the
deletion or inactivation of paternally imprinted genes on human chromosome 15q11-q13 …

Wnt-signal transduction through β-catenin is thought to require the inhibition of GSK3 by
Frat/GBP. To investigate the role of Frat in mammalian development, we have generated …