Systemic lupus erythematosus (SLE) is an autoimmune disease characterised by the loss of
self-tolerance and formation of nuclear autoantigens and immune complexes resulting in …

Women have stronger immune responses to infections and vaccination than men.
Paradoxically, the stronger immune response comes at a steep price, which is the high …

In addition to determining biological sex, sex hormones are known to influence health and
disease via regulation of immune cell activities and modulation of target-organ susceptibility …

Inflammaging is characterized by the upregulation of the inflammatory response that occurs
with advancing age; its roots are strongly embedded in evolutionary theory. Inflammaging is …

Objective: Systemic lupus erythematosus (SLE) is a complex disease with variable
presentations, course and prognosis. We sought to develop evidence-based …

Objective To describe a new systemic lupus erythematosus (SLE) responder index (SRI)
based on a belimumab phase II SLE trial and demonstrate its potential utility in SLE clinical …

Objective Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that
predominantly affects women. Despite isolated reports of patients with coexisting …

Introduction The circulation of large amounts of dehydroepiandrosterone (DHEA) and its
sulfated derivative (DHEA‐S) suggests a physiological role in human physiology. In the …

The enhanced immunoreactivity in females is a double-edged sword that provides better
protection against infections, but may lead to enhanced autoreactivity and thereby contribute …

Systemic lupus erythematosus (SLE) affects women more frequently than men, similar to the
female predilection for other autoimmune diseases. Moreover, male patients with SLE …