Ischemic stroke is one of the significant causes of morbidity and mortality, affecting millions
of people across the globe. Cell injury in the infarct region is an inevitable consequence of …

Irrespective of the morphological features of end-stage cell death (that may be apoptotic,
necrotic, autophagic, or mitotic), mitochondrial membrane permeabilization (MMP) is …

p53 induces apoptosis by target gene regulation and transcription-independent signaling.
However, a mechanism for the latter was unknown. We recently reported that a fraction of …

N6-methyladenosine (m 6 A) is the most pervasive RNA modification and is recognized as a
novel epigenetic regulation in RNA metabolism. Although the m 6 A modification involves …

The tumor suppressor and transcription factor p53 is a key modulator of cellular stress
responses, and activation of p53 can trigger apoptosis in many cell types including neurons …

One of the mechanisms by which chemotherapeutics destroy cancer cells is by inducing
apoptosis. Apoptosis can be activated through several different signalling pathways, but …

Mitochondria are vital for cellular bioenergetics and play a central role in determining the
point-of-no-return of the apoptotic process. As a consequence, mitochondria exert a dual …

Ischemic stroke is a leading cause of morbidity and death, with the outcome largely
determined by the amount of hypoxia-related neuronal death in the affected brain regions …

The regulation of neutrophil lifespan by induction of apoptosis is critical for maintaining an
effective host response and preventing excessive inflammation. The hypoxia-inducible factor …

The contributions of γδ T-cells to immunity to infection or tumors critically depend on their
activation and differentiation into effectors capable of secreting cytokines and killing infected …