Therapeutic targeting of microtubule affinity‐regulating kinase 4 in cancer and neurodegenerative diseases
Microtubule affinity‐regulating kinase 4 (MARK4) is a member of the Ser/Thr protein kinase
family, phosphorylates the microtubule‐connected proteins and plays a vital role in causing …
family, phosphorylates the microtubule‐connected proteins and plays a vital role in causing …
[HTML][HTML] Genomic variations in the structural proteins of SARS-CoV-2 and their deleterious impact on pathogenesis: a comparative genomics approach
A continual rise in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection
causing coronavirus disease (COVID-19) has become a global threat. The main problem …
causing coronavirus disease (COVID-19) has become a global threat. The main problem …
[HTML][HTML] Comparative analysis of web-based programs for single amino acid substitutions in proteins
Single amino-acid substitution in a protein affects its structure and function. These changes
are the primary reasons for the advent of many complex diseases. Analyzing single point …
are the primary reasons for the advent of many complex diseases. Analyzing single point …
[HTML][HTML] Impact of deleterious mutations on structure, function and stability of serum/glucocorticoid regulated kinase 1: a gene to diseases correlation
Serum and glucocorticoid-regulated kinase 1 (SGK1) is a Ser/Thr protein kinase involved in
regulating cell survival, growth, proliferation, and migration. Its elevated expression and …
regulating cell survival, growth, proliferation, and migration. Its elevated expression and …
Identification of novel c-Kit inhibitors from natural sources using virtual screening and molecular dynamics simulations
Abstract The Mast/Stem cell growth factor receptor Kit (c-Kit), a Proto-oncogene c-Kit, is a
tyrosine-protein kinase involved in cell differentiation, proliferation, migration, and survival …
tyrosine-protein kinase involved in cell differentiation, proliferation, migration, and survival …
Frustration analysis of TBK1 missense mutations reported in ALS/FTD and cancer patients
Abstract Tank-binding kinase 1 (TBK1) is a multifunctional kinase having essential roles in
cellular processes, autophagy/mitophagy, and selective clearance of damaged proteins …
cellular processes, autophagy/mitophagy, and selective clearance of damaged proteins …
Investigating the role of thymol as a promising inhibitor of pyruvate dehydrogenase kinase 3 for targeted cancer therapy
Protein kinases have emerged as major contributors to various diseases. They are currently
exploited as a potential target in drug discovery because they play crucial roles in cell …
exploited as a potential target in drug discovery because they play crucial roles in cell …
Dynamics of TUBB protein with five majorly occurring natural variants: a risk of cortical dysplasia
V Janakiraman, M Sudhan, KJ Alzahrani… - Journal of Molecular …, 2023 - Springer
Beta-tubulin (TUBB) protein is one of the components of the microtubule cytoskeleton that
plays a critical role in the central nervous system. Genetic variants of TUBB cause cortical …
plays a critical role in the central nervous system. Genetic variants of TUBB cause cortical …
Enriching Anticancer Drug Pipeline with Potential Inhibitors of Cyclin-Dependent Kinase-8 Identified from Natural Products
Cyclin-dependent kinase 8 (CDK8) is highly expressed in various cancers and common
complex human diseases, and an important therapeutic target for drug discovery and …
complex human diseases, and an important therapeutic target for drug discovery and …
[HTML][HTML] Investigating the mechanism of inhibition of cyclin-dependent kinase 6 inhibitory potential by selonsertib: Newer insights into drug repurposing
Cyclin-dependent kinases (CDKs) play significant roles in numerous physiological, and are
considered an attractive drug target for cancer, neurodegenerative, and inflammatory …
considered an attractive drug target for cancer, neurodegenerative, and inflammatory …