[HTML][HTML] Gut microbiota-derived bile acids in intestinal immunity, inflammation, and tumorigenesis

J Cai, L Sun, FJ Gonzalez - Cell host & microbe, 2022 - cell.com
Inflammatory bowel disease (IBD) and colorectal cancer (CRC) are heterogeneous intestinal
diseases that threaten the health of an increasing number of individuals as their lifestyles …

Microbiome risk profiles as biomarkers for inflammatory and metabolic disorders

A Metwaly, S Reitmeier, D Haller - Nature reviews Gastroenterology & …, 2022 - nature.com
The intestine harbours a complex array of microorganisms collectively known as the gut
microbiota. The past two decades have witnessed increasing interest in studying the gut …

Gut microbiota-derived metabolites as key actors in inflammatory bowel disease

A Lavelle, H Sokol - Nature reviews Gastroenterology & hepatology, 2020 - nature.com
A key role of the gut microbiota in the establishment and maintenance of health, as well as in
the pathogenesis of disease, has been identified over the past two decades. One of the …

Microbial genes and pathways in inflammatory bowel disease

M Schirmer, A Garner, H Vlamakis… - Nature Reviews …, 2019 - nature.com
Perturbations in the intestinal microbiome are implicated in inflammatory bowel disease
(IBD). Studies of treatment-naive patients have identified microbial taxa associated with …

Gut microbiome structure and metabolic activity in inflammatory bowel disease

EA Franzosa, A Sirota-Madi, J Avila-Pacheco… - Nature …, 2019 - nature.com
The inflammatory bowel diseases (IBDs), which include Crohn's disease (CD) and ulcerative
colitis (UC), are multifactorial chronic conditions of the gastrointestinal tract. While IBD has …

[HTML][HTML] Microbial tryptophan catabolites in health and disease

HM Roager, TR Licht - Nature communications, 2018 - nature.com
Accumulating evidence implicates metabolites produced by gut microbes as crucial
mediators of diet-induced host-microbial cross-talk. Here, we review emerging data …

[HTML][HTML] Systems biology and multi-omics integration: viewpoints from the metabolomics research community

FR Pinu, DJ Beale, AM Paten, K Kouremenos… - Metabolites, 2019 - mdpi.com
The use of multiple omics techniques (ie, genomics, transcriptomics, proteomics, and
metabolomics) is becoming increasingly popular in all facets of life science. Omics …

[HTML][HTML] Effects of psychological, environmental and physical stressors on the gut microbiota

JP Karl, AM Hatch, SM Arcidiacono… - Frontiers in …, 2018 - frontiersin.org
Stress, a ubiquitous part of daily human life, has varied biological effects which are
increasingly recognized as including modulation of commensal microorganisms residing in …

[HTML][HTML] Microbial fermentation of dietary protein: an important factor in diet–microbe–host interaction

NE Diether, BP Willing - Microorganisms, 2019 - mdpi.com
Protein fermentation by gut microbiota contributes significantly to the metabolite pool in the
large intestine and may contribute to host amino acid balance. However, we have a limited …

A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research

M Poyet, M Groussin, SM Gibbons, J Avila-Pacheco… - Nature medicine, 2019 - nature.com
Our understanding of how the gut microbiome interacts with its human host has been
restrained by limited access to longitudinal datasets to examine stability and dynamics, and …