Adolescent and young adult (AYA) patients with cancer have not attained the same
improvements in overall survival as either younger children or older adults. One possible …

Background Since the introduction of breast-conserving treatment, various radiation doses
after lumpectomy have been used. In a phase 3 randomised controlled trial, we investigated …

Decreasing the burden of radiation therapy (RT) for breast cancer includes, next to complete
omission, several ways to tailor the extent of RT. Possible options for this include lowering of …

BRCA1 inactivation is a frequent event in basal-like breast carcinomas (BLC). However,
BRCA1 can be inactivated by multiple mechanisms and determining its status is not a trivial …

Purpose: Previously, we developed a radiosensitivity molecular signature [radiosensitivity
index (RSI)] that was clinically validated in 3 independent datasets (rectal, esophageal, and …

Purpose: An unmet clinical need in breast cancer management is the accurate identification
of patients who will benefit from adjuvant radiotherapy. We hypothesized that integration of …

PURPOSE Most patients with early-stage breast cancer are treated with adjuvant
radiotherapy (RT) after breast-conserving surgery (BCS) to prevent locoregional recurrence …

Motivation: Measurements are commonly taken from two phenotypes to build a classifier,
where the number of data points from each class is predetermined, not random. In this …

Purpose To evaluate the effect of adjuvant radiotherapy (RT) after breast conservation
surgery in different breast cancer subtypes in a large, randomized clinical trial with long-term …

Purpose Recently, we developed radiosensitivity (RSI), a clinically validated molecular
signature that estimates tumor radiosensitivity. In the present study, we tested whether …