Glycosylation reactions mainly catalyzed by glycosyltransferases (Gts) occur almost
everywhere in the biosphere, and always play crucial roles in vital processes. In order to …

The treatment of bacterial infection is one of the most challenging tasks in the biomedical
field. Antibiotics were developed over 70 years and are regarded as the most efficient type of …

The aureolic acid-type polyketide mithramycin (MTM) has a remarkable cytotoxicity against a
variety of human tumors and has been used for the treatment of several types of cancer …

The bacteria harbored by fungus-growing ants produce a variety of small molecules that
help maintain a complex multilateral symbiosis. In a survey of antifungal compounds from …

Ribosome stalling at polyproline stretches is common and fundamental. In bacteria,
translation elongation factor P (EF-P) rescues such stalled ribosomes, but only when it is …

Tetracycline (TC) natural products possess a variety of remarkable bioactivities and diverse
structures. They are an important and fertile source for developing novel drugs. As one of the …

We report the identification of the ter gene cluster responsible for the formation of the p-
terphenyl derivatives terfestatins B and C and echoside B from the Appalachian …

Tetracenomycins and elloramycins are polyketide natural products produced by several
actinomycetes that exhibit antibacterial and anticancer activities. They inhibit ribosomal …

Mithramycin is an antitumor compound of the aureolic acid family produced by Streptomyces
argillaceus. It has been used to treat several types of cancer including testicular carcinoma …

Thiomarinol is a naturally occurring double‐headed antibiotic that is highly potent against
methicillin‐resistant Staphylococcus aureus. Its structure comprises two antimicrobial …