Different neuroplastic processes can occur along the nociceptive pathways and may be
important in the transition from acute to chronic pain and for diagnosis and development of …

Tricyclic antidepressants and serotonin noradrenaline reuptake inhibitors are used to treat
chronic pain, such as neuropathic pain. Why antidepressants are effective for treatment of …

Injury to or disease of the nervous system can invoke chronic and sometimes intractable
neuropathic pain. Many parallel, interdependent, and time-dependent processes, including …

Neuropathic pain (NeP) can result from sources as varied as nerve compression,
channelopathies, autoimmune disease, and incision. By identifying the neurobiological …

Introduction: Given our improved understanding of the role of central sensitization (CS) in
many patients with chronic pain, it seems rational to account for CS during treatment. Areas …

The gabapentinoid drugs gabapentin and pregabalin are key front‐line therapies for various
neuropathies of peripheral and central origin. Originally designed as analogs of GABA, the …

Studies have suggested that quantitative sensory testing (QST) might hold a predictive value
for the development of chronic postoperative pain and the response to pharmacological …

Neuropeptides play important modulatory roles throughout the nervous system, functioning
as direct effectors or as interacting partners with other neuropeptide and neurotransmitter …

Aim To provide an overview of mechanisms underlying craniofacial pain; to highlight
peripheral and central adaptations that may promote chronification of pain in craniofacial …

Descending controls, comprising pathways that originate in midbrain and brainstem regions
and project onto the spinal cord, have long been recognised as key links in the multiple …