Chemoprevention strategies reduce malaria disease and death, but the efficacy of anti-
malarial drugs used for chemoprevention is perennially threatened by drug resistance. This …

Understanding and controlling the spread of antimalarial resistance, particularly to
artemisinin and its partner drugs, is a top priority. Plasmodium falciparum parasites resistant …

Summary Background The Greater Mekong subregion is a recurrent source of antimalarial
drug resistance in Plasmodium falciparum malaria. This study aimed to characterise the …

Introduction Since the spread of chloroquine resistance in Plasmodium falciparum in the
1960s, recommendations have been made on how to respond to antimalarial resistance …

Emergence and spread of resistance in Plasmodium falciparum to the frontline treatment
artemisinin-based combination therapies (ACTs) in the epicenter of multidrug resistance of …

The emergence of artemisinin resistance is a major obstacle to the global malaria
eradication/elimination programs. Artemisinin is a very fast-acting antimalarial drug and is …

Background: National Malaria Control Programmes (NMCPs) currently make limited use of
parasite genetic data. We have developed GenRe-Mekong, a platform for genetic …

Intensified treatment and control efforts since the early 2000s have dramatically reduced the
burden of Plasmodium falciparum malaria. However, drug resistance threatens to derail this …

The deployment of artesunate for severe malaria and the artemisinin combination therapies
(ACTs) for uncomplicated malaria has been a major advance in antimalarial therapeutics …

Artemisinin derivatives are the cornerstone of current antimalarial treatment, both for severe
malaria (injectable artesunate) and uncomplicated malaria [artemisinin combination therapy …