Human fungal infections are a historically neglected area of disease research, yet they
cause more than 1.5 million deaths every year. Our understanding of the pathophysiology of …

Human activities have significantly impacted the environment and are changing our climate
in ways that will have major consequences for ourselves, and endanger animal, plant and …

The capsule of Cryptococcus neoformans is its dominant virulence factor and plays a key
role in the biology of this fungus. In this essay, we focus on the capsule as a cellular …

Environmental pathogens move from ecological niches to mammalian hosts, requiring
adaptation to dramatically different environments. Microbes that disseminate farther …

Fungal infections are an increasing threat to global public health. There are more than six
million fungal species worldwide, but less than 1% are known to infect humans. Most of …

The blood-brain barrier (BBB) protects the central nervous system (CNS) by restricting the
passage of molecules and microorganisms. Despite this barrier, however, the fungal …

Much of medical research relies on animal models to deepen knowledge of the causes of
animal and human diseases, as well as to enable the development of innovative therapies …

The recognition of fungal cells by the host immune system is key during the establishment of
a protective anti-fungal response. Even though the immune system has evolved a vast …

The function of macrophages in vitro is linked to their metabolic rewiring. However,
macrophage metabolism remains poorly characterized in situ. Here, we used two-photon …

CD4+ T cells are at the nexus of the innate and adaptive arms of the immune system.
However, little is known about the evolutionary history of CD4+ T cells, and it is unclear …