A survey of protein databases indicates that the majority of enzymes exist in oligomeric
forms, with about half of those found in the UniProt database being homodimeric …

Elucidating intracellular drug targets is a difficult problem. While machine learning analysis
of omics data has been a promising approach, going from large-scale trends to specific …

Antibiotic resistance is a worldwide challenge. A potential approach to block resistance is to
simultaneously inhibit WT and known escape variants of the target bacterial protein. Here …

Enzymatic parameters are classically determined in vitro, under conditions that are far from
those encountered in cells, casting doubt on their physiological relevance. We developed a …

Non-Destructive Material Characterization Methods provides readers with a trove of
theoretical and practical insight into how to implement different non-destructive testing …

The rampant variability in codon bias existing between bacterial genomes is expected to
interfere with horizontal gene transfer (HGT), a phenomenon that drives bacterial adaptation …

Aniridia is a rare panocular disease caused by gene mutation in the PAX6, which is
essential for eye development. Aniridia is inherited in an autosomal dominant manner, but …

Non-destructive testing (NDT) is an analysis technique used by industry to evaluate the
properties of a material, component, structure, or system for characteristic differences or …

Understanding intracellular antibiotic targeting and the associated mechanisms leading to
bacterial growth inhibition has been a difficult problem. Here, we discovered the additional …

Antibiotic resistance is a worldwide challenge. A potential approach to block resistance is to
simultaneously inhibit WT and known escape variants of the target bacterial protein. Here …