Steroidogenesis, the processes by which cholesterol is converted to steroid hormones,
involves transport proteins, enzymes, redox partners and cofactors. Most steroidogenic …

Glucocorticoid action on target tissues is determined by the density of “nuclear” receptors
and intracellular metabolism by the two isozymes of 11β-hydroxysteroid dehydrogenase …

It is estimated that 2% to 3% of the population are currently prescribed systemic or topical
glucocorticoid treatment. The potent anti-inflammatory action of glucocorticoids to deliver …

The pentose phosphate pathway (PPP) is a fundamental component of cellular metabolism.
The PPP is important to maintain carbon homoeostasis, to provide precursors for nucleotide …

Recent years have seen significant advances in our understanding of the development and
function of the adrenal gland together with further insights into the physiologic and …

Liquid chromatography tandem mass spectrometry (LC/MS/MS) is replacing classical
methods for steroid hormone analysis. It requires small sample volumes and has given rise …

Steroid biosynthesis and metabolism are reflected by the serum steroid metabolome and, in
even more detail, by the 24-hour urine steroid metabolome, which can provide unique …

Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the global obesity
and metabolic disease epidemic and is rapidly becoming the leading cause of liver cirrhosis …

Glucocorticoids have profound effects on brain development and adult CNS function. Excess
or insufficient glucocorticoids cause myriad abnormalities from development to ageing. The …

Abstract 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) interconverts the inactive
glucocorticoid cortisone and its active form cortisol. It is widely expressed and, although …