The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders
WL Miller, RJ Auchus - Endocrine reviews, 2011 - academic.oup.com
Steroidogenesis, the processes by which cholesterol is converted to steroid hormones,
involves transport proteins, enzymes, redox partners and cofactors. Most steroidogenic …
involves transport proteins, enzymes, redox partners and cofactors. Most steroidogenic …
11β-hydroxysteroid dehydrogenases: intracellular gate-keepers of tissue glucocorticoid action
Glucocorticoid action on target tissues is determined by the density of “nuclear” receptors
and intracellular metabolism by the two isozymes of 11β-hydroxysteroid dehydrogenase …
and intracellular metabolism by the two isozymes of 11β-hydroxysteroid dehydrogenase …
Treating the Side Effects of Exogenous Glucocorticoids; Can We Separate the Good From the Bad?
It is estimated that 2% to 3% of the population are currently prescribed systemic or topical
glucocorticoid treatment. The potent anti-inflammatory action of glucocorticoids to deliver …
glucocorticoid treatment. The potent anti-inflammatory action of glucocorticoids to deliver …
The return of metabolism: biochemistry and physiology of the pentose phosphate pathway
The pentose phosphate pathway (PPP) is a fundamental component of cellular metabolism.
The PPP is important to maintain carbon homoeostasis, to provide precursors for nucleotide …
The PPP is important to maintain carbon homoeostasis, to provide precursors for nucleotide …
Adrenal cortex
PM Stewart - Current Opinion in Endocrinology, Diabetes and …, 1999 - journals.lww.com
Recent years have seen significant advances in our understanding of the development and
function of the adrenal gland together with further insights into the physiologic and …
function of the adrenal gland together with further insights into the physiologic and …
[HTML][HTML] Gas chromatography/mass spectrometry (GC/MS) remains a pre-eminent discovery tool in clinical steroid investigations even in the era of fast liquid …
Liquid chromatography tandem mass spectrometry (LC/MS/MS) is replacing classical
methods for steroid hormone analysis. It requires small sample volumes and has given rise …
methods for steroid hormone analysis. It requires small sample volumes and has given rise …
Steroid metabolome analysis in disorders of adrenal steroid biosynthesis and metabolism
KH Storbeck, L Schiffer, ES Baranowski… - Endocrine …, 2019 - academic.oup.com
Steroid biosynthesis and metabolism are reflected by the serum steroid metabolome and, in
even more detail, by the 24-hour urine steroid metabolome, which can provide unique …
even more detail, by the 24-hour urine steroid metabolome, which can provide unique …
Glucocorticoids and non-alcoholic fatty liver disease
CP Woods, JM Hazlehurst, JW Tomlinson - The Journal of steroid …, 2015 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the global obesity
and metabolic disease epidemic and is rapidly becoming the leading cause of liver cirrhosis …
and metabolic disease epidemic and is rapidly becoming the leading cause of liver cirrhosis …
[HTML][HTML] 11β-hydroxysteroid dehydrogenases and the brain: from zero to hero, a decade of progress
Glucocorticoids have profound effects on brain development and adult CNS function. Excess
or insufficient glucocorticoids cause myriad abnormalities from development to ageing. The …
or insufficient glucocorticoids cause myriad abnormalities from development to ageing. The …
11β-Hydroxysteroid dehydrogenase 1: translational and therapeutic aspects
Abstract 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) interconverts the inactive
glucocorticoid cortisone and its active form cortisol. It is widely expressed and, although …
glucocorticoid cortisone and its active form cortisol. It is widely expressed and, although …