Toxoplasmosis: a pathway to neuropsychiatric disorders

S Tyebji, S Seizova, AJ Hannan, CJ Tonkin - … & Biobehavioral Reviews, 2019 - Elsevier
Toxoplasma gondii is an obligate intracellular parasite that resides, in a latent form, in the
human central nervous system. Infection with Toxoplasma drastically alters the behaviour of …

Dense granule biogenesis, secretion, and function in Toxoplasma gondii

MB Griffith, CS Pearce… - Journal of Eukaryotic …, 2022 - Wiley Online Library
Toxoplasma gondii is an obligate intracellular parasite and the causative agent of
Toxoplasmosis. A key to understanding and treating the disease lies with determining how …

[HTML][HTML] Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13

NF Gnädig, BH Stokes, RL Edwards… - PLoS …, 2020 - journals.plos.org
The emergence of artemisinin (ART) resistance in Plasmodium falciparum intra-erythrocytic
parasites has led to increasing treatment failure rates with first-line ART-based combination …

[HTML][HTML] Characterization of a Toxoplasma effector uncovers an alternative GSK3/β-catenin-regulatory pathway of inflammation

H He, MP Brenier-Pinchart, L Braun, A Kraut… - Elife, 2018 - elifesciences.org
The intracellular parasite Toxoplasma gondii, hijacks evolutionarily conserved host
processes by delivering effector proteins into the host cell that shift gene expression in a …

Reassessing the mechanics of parasite motility and host-cell invasion

I Tardieux, J Baum - Journal of Cell Biology, 2016 - rupress.org
The capacity to migrate is fundamental to multicellular and single-celled life. Apicomplexan
parasites, an ancient protozoan clade that includes malaria parasites (Plasmodium) and …

[HTML][HTML] Transcriptional modification of host cells harboring Toxoplasma gondii bradyzoites prevents IFN gamma-mediated cell death

S Seizova, U Ruparel, AL Garnham, SM Bader… - Cell host & …, 2022 - cell.com
Toxoplasma gondii develops a latent infection in the muscle and central nervous system that
acts as a reservoir for acute-stage reactivation in vulnerable patients. Little is understood …

The broad host range pathogen Sclerotinia sclerotiorum produces multiple effector proteins that induce host cell death intracellularly

TE Newman, H Kim, Y Khentry, KH Sohn… - Molecular Plant …, 2023 - Wiley Online Library
Sclerotinia sclerotiorum is a broad host range necrotrophic fungal pathogen, which causes
disease on many economically important crop species. S. sclerotiorum has been shown to …

Aspartyl protease 5 matures dense granule proteins that reside at the host-parasite interface in Toxoplasma gondii

MJ Coffey, LF Dagley, S Seizova, EA Kapp, G Infusini… - MBio, 2018 - Am Soc Microbiol
Toxoplasma gondii infects approximately 30% of the world's population, causing disease
primarily during pregnancy and in individuals with weakened immune systems. Toxoplasma …

Translocation of effector proteins into host cells by Toxoplasma gondii

S Rastogi, AM Cygan, JC Boothroyd - Current opinion in microbiology, 2019 - Elsevier
Highlights•Toxoplasma introduces ROP and GRA effectors into host cells to coopt host
functions.•ROP effector secretion occurs during invasion via an unknown mechanism.•MYR1 …

Phosphorylation in the Plasmodium falciparum Proteome: A Meta-Analysis of Publicly Available Data Sets

OJM Camacho, KA Ramsbottom… - Journal of Proteome …, 2023 - ACS Publications
Malaria is a deadly disease caused by Apicomplexan parasites of the Plasmodium genus.
Several species of the Plasmodium genus are known to be infectious to humans, of which P …