The blood–brain barrier (BBB) is a dynamic and complex interface between blood and the
central nervous system that strictly controls the exchanges between the blood and brain …

The classic theories of aging such as the free radical theory, including its mitochondria‐
related versions, have largely focused on a few specific processes of senescence …

Background and Purpose In vivo and in vitro studies have demonstrated a protective effect
of cannabidiol (CBD) in reducing infarct size in stroke models and against epithelial barrier …

The blood-brain barrier (BBB) provides a vast interface for cytokines to affect CNS function.
The BBB is a target for therapeutic intervention. It is essential, therefore, to understand how …

Previous studies have shown that modulation of the receptor-mediated cannabinoid system
during neuroinflammation can produce potent neuroprotective and anti-inflammatory effects …

Endothelial cells exert an enormous influence on blood vessels throughout the circulation,
but their impact is particularly pronounced in the brain. New concepts have emerged …

We describe a method for generating primary cultures of human brain microvascular
endothelial cells (HBMVECs). HBMVECs are derived from microvessels isolated from …

Developing therapies for central nervous system (CNS) diseases is exceedingly difficult
because of the blood–brain barrier (BBB). Notably, emerging technologies may provide …

Antiretroviral therapy (ART) shows variable blood-brain barrier penetration. This may affect
the development of neurological complications of HIV infection. In attempts to attenuate viral …

Methamphetamine (METH), a potent stimulant with strong euphoric properties, has a high
abuse liability and long-lasting neurotoxic effects. Recent studies in animal models have …