[HTML][HTML] Osteoarthritis: pathogenic signaling pathways and therapeutic targets

Q Yao, X Wu, C Tao, W Gong, M Chen, M Qu… - Signal transduction and …, 2023 - nature.com
Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …

Synovial inflammation in osteoarthritis progression

E Sanchez-Lopez, R Coras, A Torres… - Nature Reviews …, 2022 - nature.com
Osteoarthritis (OA) is a progressive degenerative disease resulting in joint deterioration.
Synovial inflammation is present in the OA joint and has been associated with radiographic …

[HTML][HTML] Prevalence trends of sitespecific osteoarthritis from 1990 to 2019: findings from the global burden of disease study 2019

H Long, Q Liu, H Yin, K Wang, N Diao… - Arthritis & …, 2022 - Wiley Online Library
Objective To estimate systematic and anatomic site–specific agestandardized prevalence
rates (ASRs) and analyze the secular trends of osteoarthritis (OA) at global, regional, and …

[HTML][HTML] Global, regional prevalence, incidence and risk factors of knee osteoarthritis in population-based studies

A Cui, H Li, D Wang, J Zhong, Y Chen, H Lu - EClinicalMedicine, 2020 - thelancet.com
Background Knee osteoarthritis (OA) is a major cause of disability in the elderly, however,
there are few studies to estimate the global prevalence, incidence, and risk factors of knee …

Osteoarthritis: pathology, diagnosis, and treatment options

B Abramoff, FE Caldera - Medical Clinics, 2020 - medical.theclinics.com
Osteoarthritis (OA) is endemic throughout the world. An estimated 30.8 million adults in the
United States and 300 million individuals worldwide are living with OA. 1, 2 It is the leading …

Global, regional and national burden of osteoarthritis 1990-2017: a systematic analysis of the Global Burden of Disease Study 2017

S Safiri, AA Kolahi, E Smith, C Hill… - Annals of the …, 2020 - ard.bmj.com
Objectives To report the level and trends of prevalence, incidence and years lived with
disability (YLDs) for osteoarthritis (OA) in 195 countries and territories from 1990 to 2017 by …

Stem cell–homing hydrogel-based miR-29b-5p delivery promotes cartilage regeneration by suppressing senescence in an osteoarthritis rat model

J Zhu, S Yang, Y Qi, Z Gong, H Zhang, K Liang… - Science …, 2022 - science.org
Osteoarthritis (OA) is a common joint disease characterized by progressive loss of cartilage
and reduction in lubricating synovial fluid, which lacks effective treatments currently. Here …

[HTML][HTML] Incidence and prevalence of patellofemoral pain: a systematic review and meta-analysis

BE Smith, J Selfe, D Thacker, P Hendrick, M Bateman… - PloS one, 2018 - journals.plos.org
Background Patellofemoral pain is considered one of the most common forms of knee pain,
affecting adults, adolescents, and physically active populations. Inconsistencies in reported …

Ageing and the pathogenesis of osteoarthritis

RF Loeser, JA Collins, BO Diekman - Nature Reviews Rheumatology, 2016 - nature.com
Ageing-associated changes that affect articular tissues promote the development of
osteoarthritis (OA). Although ageing and OA are closely linked, they are independent …

[HTML][HTML] Risk factors and burden of osteoarthritis

C Palazzo, C Nguyen, MM Lefevre-Colau… - Annals of physical and …, 2016 - Elsevier
Osteoarthritis (OA) is one of the most common joint disorders worldwide. Its prevalence is
increasing because of the growing aging of the population in developed and developing …