Friedreich's ataxia (FRDA), a neurodegenerative disease characterized by ataxia and other
neurological features, affects 1 in 50,000–100,000 individuals in the USA. However, FRDA …

Introduction Friedreich ataxia (FRDA) is a rare autosomal recessive degenerative disorder
characterized by ataxia, dysarthria, diabetes, cardiomyopathy, scoliosis, and occasionally …

Friedreich's ataxia is a rare disorder resulting from deficiency of frataxin, a mitochondrial
protein implicated in the synthesis of iron-sulfur clusters. Preclinical studies in mice have …

Iron–sulfur (Fe-S) clusters (ISCs) are ubiquitous cofactors essential to numerous
fundamental cellular processes. Assembly of ISCs and their insertion into apoproteins …

Friedreich ataxia (FA) is currently an incurable inherited mitochondrial disease caused by
reduced levels of frataxin (FXN). Cardiac dysfunction is the main cause of premature death …

Recent investigations have defined the pathophysiological basis of many hereditary ataxias
(HAs), including loss-of-function as well as gain-of-function mechanisms at either the RNA or …

Iron is an essential trace element required for several vital physiological and developmental
processes, including erythropoiesis, bone, and neuronal development. Iron metabolism and …

Friedreich ataxia (FRDA), the most common inherited ataxia, is caused by transcriptional
silencing of the nuclear FXN gene, encoding the essential mitochondrial protein frataxin …

Friedreich's ataxia (FA) is one of the most frequent inherited recessive ataxias characterized
by a progressive sensory and spinocerebellar ataxia. The main causative mutation is a GAA …

Friedreich's ataxia (FA) is a devastating, multi-systemic neurodegenerative disease affecting
thousands of people worldwide. We previously reported that oxygen is a key environmental …