Dysfunction of VAMP-associated protein (VAP) is associated with neurodegeneration, both
Amyotrophic Lateral Sclerosis and Parkinson's disease. Here we summarize what is known …

In the fatal neurodegenerative disease amyotrophic lateral sclerosis (ALS), motor neurons
degenerate with signs of organelle fragmentation, free radical damage, mitochondrial Ca2+ …

Here, we demonstrate that protein-coding RNA transcripts can crosstalk by competing for
common microRNAs, with microRNA response elements as the foundation of this …

A proline to serine substitution at position 56 in the gene encoding vesicle-associated
membrane protein-associated protein B (VAPB) causes some dominantly inherited familial …

The health crisis caused by the new coronavirus SARS-CoV-2 highlights the need to identify
new treatment strategies for this viral infection. During the past year, over 400 coronavirus …

Amyotrophic lateral sclerosis (ALS) is an incurable neuromuscular disease that leads to a
profound loss of life quality and premature death. Around 10% of the cases are inherited and …

Following the mutation screening of genes known to cause amyotrophic lateral sclerosis
(ALS) in index cases from 107 familial ALS (FALS) kindred, a point mutation was identified in …

Several diverse proteins are linked genetically/pathologically to neurodegeneration in
amyotrophic lateral sclerosis (ALS) including SOD1, TDP-43 and FUS. Using a variety of …

A proline-to-serine substitution at position 56 in the gene encoding vesicle-associated
membrane protein-associated protein B (VAPB; VAPBP56S) causes some dominantly …

Vesicle-associated membrane protein (VAMP)-associated proteins (VAPs) are ubiquitous
ER-resident tail-anchored membrane proteins in eukaryotic cells. Their N-terminal major …