The discovery of both cytotoxic T lymphocyte-associated antigen 4 (CTLA4) and
programmed cell death protein 1 (PD1) as negative regulators of antitumour immunity led to …

Antibodies can impact pathogens in the presence or in the absence of effector cells or
effector molecules such as complement, and experiments can often sort out with precision …

Inflammation is a common medical complication in colorectal cancer (CRC) patients, which
plays significant roles in tumor progression and immunosuppression. However, the …

Neutrophils are best known for their critical role in host defense, for which they utilize
multiple innate immune mechanisms, including microbe-associated pattern recognition …

Now available in a thoroughly revised Twelfth Edition, Wintrobe's Clinical Hematology
continues to be an industry leader with its ability to correlate basic science with the clinical …

We analyzed a genetic polymorphism of Fcγ receptor IIIa (CD16) that is present on position
158 (Phe or Val) in the membrane-proximal, IgG-binding domain. With a polymerase chain …

A novel polymorphism in the extracellular domain 2 (EC2) of FcgammaRIIIA affects ligand
binding by natural killer (NK) cells and monocytes from genotyped homozygous normal …

The complement system comprises several fluid-phase and membrane-associated proteins.
Under physiological conditions, activation of the fluid-phase components of complement is …

Obinutuzumab (GA101) is a glycoengineered type 2 CD20 antibody with enhanced CD16A-
binding and natural killer–mediated cytotoxicity. CD16B is highly homologous to CD16A and …

Despite considerable advances in the understanding of the pathogenesis of meningococcal
disease, this infection remains a major cause of morbidity and mortality globally. The role of …