During an epidemic or pandemic, the primary task is to rapidly develop precise diagnostic
approaches and effective therapeutics. Oligonucleotide aptamer-based pathogen detection …

The invention of the in vitro selection technique, or SELEX (Systematic Evolution of Ligands
by EXponential enrichment), in the early 1990s, identified single-stranded (ss) nucleic acid …

Fast and effective detection of the causative agent of malaria in humans, protozoan
Plasmodium parasites, is of crucial importance for increasing the effectiveness of treatment …

Background Aptamers refer to the artificially synthesized nucleic acid sequences
(DNA/RNA) that can bind to a wide range of targets with high affinity and specificity, which …

Oligonucleotide-based aptamers, which have a three-dimensional structure with a single-
stranded fragment, feature various characteristics with respect to size, toxicity, and …

Pancreatic cancer is a high degree malignant tumor which makes its diagnosis and
treatment highly critical. The effect of conventional chemotherapy for pancreatic cancer is …

The methyl erythritol phosphate (MEP) pathway of isoprenoid biosynthesis is essential for
malaria parasites and also for several human pathogenic bacteria, thus representing an …

Extracts of the plant Glycyrrhiza glabra (licorice) are used in traditional medicine to treat
malaria. The main active components are the saponin glycyrrhizin (GLR) and its active …

Plasmodium falciparum is the causative agent of the deadliest human malaria. New
molecules are needed that can specifically bind to erythrocytes that are infected with P …

Malaria remains as one of the major public health problems worldwide. About 228 million
cases occurred in 2018 only, with Africa bearing about 93% of the cases. Asymptomatic …