Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease

Z Chen, R Tian, Z She, J Cai, H Li - Free Radical Biology and Medicine, 2020 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) has emerged as the most common chronic liver
disease worldwide and is strongly associated with the presence of oxidative stress …

Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling

Y Wang, R Branicky, A Noë, S Hekimi - Journal of Cell Biology, 2018 - rupress.org
Superoxide dismutases (SODs) are universal enzymes of organisms that live in the
presence of oxygen. They catalyze the conversion of superoxide into oxygen and hydrogen …

ROS in platelet biology: functional aspects and methodological insights

E Masselli, G Pozzi, M Vaccarezza… - International journal of …, 2020 - mdpi.com
Reactive oxygen species (ROS) and mitochondria play a pivotal role in regulating platelet
functions. Platelet activation determines a drastic change in redox balance and in platelet …

Mitochondrial metabolism in astrocytes regulates brain bioenergetics, neurotransmission and redox balance

J Rose, C Brian, A Pappa, MI Panayiotidis… - Frontiers in …, 2020 - frontiersin.org
In the brain, mitochondrial metabolism has been largely associated with energy production,
and its dysfunction is linked to neuronal cell loss. However, the functional role of …

[HTML][HTML] Reactive oxygen species, nutrition, hypoxia and diseases: Problems solved?

A Görlach, EY Dimova, A Petry, A Martínez-Ruiz… - Redox biology, 2015 - Elsevier
Within the last twenty years the view on reactive oxygen species (ROS) has changed; they
are no longer only considered to be harmful but also necessary for cellular communication …

Reactive oxygen species: beyond their reactive behavior

A Tauffenberger, PJ Magistretti - Neurochemical Research, 2021 - Springer
Cellular homeostasis plays a critical role in how an organism will develop and age.
Disruption of this fragile equilibrium is often associated with health degradation and …

ROS production in phagocytes: why, when, and where?

S Dupré-Crochet, M Erard… - Journal of leukocyte …, 2013 - academic.oup.com
In the phagocytosis field, ROS production by the phagocyte NOX has been associated with
pathogen killing for the last 50 years. Since the discovery of nonphagocyte NOX, numerous …

Mitochondria, oxidative stress and nonalcoholic fatty liver disease: A complex relationship

A Karkucinska‐Wieckowska… - European journal of …, 2022 - Wiley Online Library
According to the 'multiple‐hit'hypothesis, several factors can act simultaneously in
nonalcoholic fatty liver disease (NAFLD) progression. Increased nitro‐oxidative (nitroso …

Mitochondria as a source of reactive oxygen and nitrogen species: from molecular mechanisms to human health

TR Figueira, MH Barros, AA Camargo… - Antioxidants & redox …, 2013 - liebertpub.com
Mitochondrially generated reactive oxygen species are involved in a myriad of signaling and
damaging pathways in different tissues. In addition, mitochondria are an important target of …

Mitochondrial oxidative stress and “mito-inflammation”: actors in the diseases

S Patergnani, E Bouhamida, S Leo, P Pinton… - Biomedicines, 2021 - mdpi.com
A decline in mitochondrial redox homeostasis has been associated with the development of
a wide range of inflammatory-related diseases. Continue discoveries demonstrate that …