Cancer is a group of diseases in which cells divide continuously and excessively. Cell
division is tightly regulated by multiple evolutionarily conserved cell cycle control …

BACKGROUND Cyclins and cyclin-dependent kinases (CDKs) drive cell division. Of
particular importance to the cancer field are D-cyclins, which activate CDK4 and CDK6. In …

Summary The Cdk-Rb-E2F pathway integrates external and internal signals to control
progression at the G1/S transition of the mammalian cell cycle. Alterations in this pathway …

Efficient S phase entry is essential for development, tissue repair, and immune defences.
However, hyperactive or expedited S phase entry causes replication stress, DNA damage …

CDK2 is a core cell-cycle kinase that phosphorylates many substrates to drive progression
through the cell cycle. CDK2 is hyperactivated in multiple cancers and is therefore an …

In mammalian cells, the decision to proliferate is thought to be irreversibly made at the
restriction point of the cell cycle,, when mitogen signalling engages a positive feedback loop …

External signaling controls cell-cycle entry until cells irreversibly commit to the cell cycle to
ensure faithful DNA replication. This process is tightly regulated by cyclin-dependent …

With age, skeletal muscle stem cells (MuSCs) activate out of quiescence more slowly and
with increased death, leading to defective muscle repair. To explore the molecular …

In the commonly accepted paradigm for control of the mammalian cell cycle, sequential
cyclin-dependent kinase (CDK) and cyclin activities drive the orderly transition from G1 to S …

Since their discovery as drivers of proliferation, cyclin-dependent kinases (CDKs) have been
considered therapeutic targets. Small molecule inhibitors of CDK4/6 are used and tested in …